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📘 How a fever changes body temperature

Follow immune signals, hypothalamic set points, shivering, sweating, and the difference from hyperthermia.

lessons

~10 min

to learn

🔬 Science

subject

Adults

level

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What you’ll learn

Set point
Pyrogens
PGE2
Chills
Plateau
Sweating
Immune purpose
Hyperthermia
Measurement
Resolution

Questions this course answers

What changes during a fever?

Fever is a regulated elevation caused by an upward set-point shift.

What does PGE2 do?

PGE2 acts on hypothalamic neurons in the fever pathway.

Why can chills occur during a rising fever?

The body recruits heat conservation and shivering to reach the elevated set point.

What happens when the set point falls?

Current temperature is then above target, so heat-loss responses activate.

How is hyperthermia different from fever?

Hyperthermia is unregulated overheating rather than a set-point reset.

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