Part 11

PROPERTIES.--A nearly colorless, or reddish-brown liquid of a strong disagreeable and creosote-like odor, and gradually turning darker on exposure to the air and light. Soluble in fifteen parts of water.

PHENOL--ACIDUM CARBOLICUM--CARBOLIC ACID

DERIVATION.--Obtained from crude carbolic acid by agitation with caustic soda, heating to 338° F., and adding hydrochloric acid. Then by agitation with sodium chloride, digestion with calcium chloride, and distillation at a temperature between 336° F. and 374° F. and finally by crystallization.

PROPERTIES.--Phenol in its pure state is a solid at ordinary temperatures, crystallizing in minute plates or long rhomboidal needles, white or colorless, of a peculiar odor recalling that of creosote, and an acrid burning taste. It is likely to be colored pinkish or brown under the influence of light and air. Soluble in about 19.6 parts of water, and very soluble in alcohol, ether, chloroform, glycerin, fixed and volatile oils.

ACTIONS.--Phenol in large and undiluted doses is an irritant and narcotic poison; it is used as an antiseptic, parasiticide, antiferment and sometimes used as a local anaesthetic or anodyne in a 2 to 5 per cent solution; also as a caustic, but should not be used as a caustic as a burn from it heals very slowly.

USES.--Internally as a gastric sedative in small doses for vomiting in dogs; is administered in various contagious and infectious diseases with the view of preventing or arresting the development of micro-organisms; it coagulates albumen, is not nearly so active as bichloride of mercury; 1 part to 500 parts of water prevents the growth of anthrax and other bacilli. Full doses produce gastro-enteritis, and collapse, which may end fatally; it is a muscular and nerve paralyzer, both internally and externally, it kills by paralyzing the muscles of respiration and the heart. It is chiefly eliminated from the system by the kidneys, giving the urine a brownish color.

IN SURGERY.--A three to five per cent solution is used for washing out wounds, a two to three per cent for hands, and for itching of the skin, carbolic acid three or four drachms, glycerine two ounces to one pint of water. Do not use over large surface on dogs and not at all on cats.

Phenol treatment for Tetanus, which has given very good results and I would recommend one drachm in three ounces of water, injected hypodermically in the region of neck and shoulder every two or three hours until twelve injections were given and less frequently thereafter.

DOSES.--Of the phenol: Horses and cattle, 10 to 40 grs.; sheep and pigs, 5 to 10 grs.; dogs, ¹⁄₂ to 1 gr., well diluted.

TOXICOLOGY.--Dogs and cats are especially susceptible to the action of carbolic acid, therefore great care must be exercised when washing, especially cats, with any preparation containing carbolic acid. Disinfecting and deodorizing cat’s quarters with any preparation containing carbolic acid makes them sick.

ANTIDOTE.--Sulphates of soda or magnesia. Atropine sulphate hypodermically is a very valuable antidote. Alcohol and vinegar have been used with good results, both internally and externally.

ACIDUM SALICYLICUM--SALICYLIC ACID

An organic acid, existing naturally in combination in various plants, but largely prepared synthetically from carbolic acid.

DERIVATION.--Made by passing carbonic dioxide through sodium carbolate at a temperature of 428° F. (220° C.). 2 NaC₆H₅O (sodium carbolate) + CO₂ = Na₂C₇H₄O₃ (sodium salicylate) + C₆H₆O (phenol). Sodium salicylate is treated with hydrochloric acid when salicylic acid is precipitated.

PROPERTIES.--Light, fine, white, needle-shaped crystals, odorless, having a sweetish, afterwards acrid taste; permanent in air. Soluble in alcohol, ether and hot water; borax increases its solubility.

DOSE.--Horses, 2 to 6 drs.; cattle, ¹⁄₂ to 1 oz.; sheep, 1 to 2 drs.; pigs, 30 to 40 grs.; dogs, 5 to 20 grs.; should be given well diluted; large doses are recommended for fevers, but smaller doses more often repeated in rheumatism.

SODII SALICYLAS--SODIUM SALICYLAS

DERIVATION.--Made by the action of salicylic acid on sodium carbonate. The solution is filtered and heated to expel carbon dioxide.

PROPERTIES.--A white amorphous or crystalline powder or scales; odorless and having a sweetish, saline taste. Permanent in air. Soluble in water, alcohol and glycerine.

DOSE.--Same as for salicylic acid.

PHENYLIS SALICYLAS--PHENYL SALICYLATE (Salol)

DERIVATION.--Made by heating salicylic and carbolic acids with phosphorous pentachloride.

PROPERTIES.--A white crystalline powder; odorless, or having a faintly aromatic odor, and almost tasteless. Permanent in air. Insoluble in water, soluble in ten parts of alcohol and readily soluble in chloroform.

DOSE.--Same as for salicylic acid.

ACTIONS.--Salicylic acid, sodium salicylate and phenyl salicylate are powerful antiseptic, anti-rheumatic, diaphoretic, cardiac depressant, antiferment and antipyretic. Salicylic acid is in addition irritant and astringent, continued in large doses is apt to derange digestion; best to be administered on a full stomach.

USES.--For acute rheumatism, influenza, strangles and purpura where there is much sloughing; also as a surgical wash, salicylic acid one part, borax one part to thirty or forty parts of water. Salicylic acid is a more powerful antiseptic than carbolic acid. Salicylic of soda is freely antiseptic. Salicylic acid is highly recommended in intestinal flatulence, given in two drachm doses with one ounce of aromatic spirits of ammonia. In gastric-flatulence give two drachms in capsule, repeat in half hour if necessary.

ACONITUM--ACONITE--MONKSHOOD

DERIVATION.--Aconite is obtained from the root of aconitum napellus, which grows in Northwestern North America, Europe and Asia in mountainous regions, and cultivated in the United States for its beautiful flowers.