An Examination of Weismannism

CHAPTER I.. Statement of Weismann’s System Up to the Year 1886[1].

STATEMENT OF WEISMANN’S SYSTEM UP TO THE YEAR 1886.

SEEING that Professor Weismann’s theory of heredity, besides being somewhat elaborate in itself, is presented in a series of disconnected essays, originally published at different times, it is a matter of no small difficulty to gather from the present collection of them a complete view of the system as a whole. Therefore I propose to give a brief sketch of his several cognate theories, arranged in a manner calculated to show their logical connexion one with another. And, in order also to show the relation in which his resulting theory of heredity stands to what has hitherto been the more usual way of regarding the facts, I will begin by furnishing a similarly condensed account of Mr. Darwin’s theory upon the subject. It will be observed that these two theories constitute the logical extremes of explanatory thought; and therefore it may be said, in a general way, that all other modern theories of heredity—such as those of Spencer, Häckel, Elsberg, Galton, Nägeli, His, Brooks, Hertwig, and De Vries—occupy positions more or less intermediate between these two extremes. Therefore, also, we need not wait to consider these intermediate theories.

“When closely analyzed, Mr. Darwin’s theory—or the “provisional hypothesis of Pangenesis”—will be found to embody altogether seven assumptions, namely:—

1. That all the component cells of a multicellular organism throw off inconceivably minute germs, or “gemmules,” which are then dispersed throughout the whole system.

2. That these gemmules, when so dispersed and supplied with proper nutriment, multiply by self-division, and, under suitable conditions, are capable of developing into physiological cells like those from which they were originally and severally derived.

3. That, while still in this gemmular condition, these cell-seeds have for one another a mutual affinity, which leads to their being collected from all parts of the system by the reproductive glands of the organism; and that, when so collected, they go to constitute the essential material of the sexual elements—ova and spermatozoa being thus aggregated packets of gemmules, which have emanated from all the cells of all the tissues of the organism.

4. That the development of a new organism, out of the fusion of two such packets of gemmules, is due to a summation of all the developments of some of the gemmules which these two packets contain.

5. That a large proportional number of the gemmules in each packet, however, fail to develop, and are then transmitted in a dormant state to future generations, in any of which they may be developed subsequently—thus giving rise to the phenomena of reversion or atavism.

6. That in all cases the development of gemmules into the form of their parent cells depends on their suitable union with other partially developed gemmules, which precede them in the regular course of growth.

7. That gemmules are thrown off by all physiological cells, not only during the adult state of the organism, but during all stages of its development. Or, in other words, that the production of these cell-seeds depends upon the adult condition of parent cells: not upon that of the multicellular organism as a whole.

At first sight it may well appear that we have here a very formidable array of assumptions. But Darwin ably argues in favour of each of them by pointing to well-known analogies, drawn from the vital processes of living cells both in the protozoa and metazoa. For example, it is already a well-recognized doctrine of physiology that each cell of a metazoon, or multicellular organism, though to a large extent dependent on others, is likewise to a certain extent independent or autonomous, and has the power of multiplying by self-division. Therefore, as it is certain that the sexual elements (and also buds of all descriptions) include formative material of some kind, the first assumption—or that which supposes such formative matter to be participate—is certainly not a gratuitous assumption.

Again, the second assumption—viz., that this particulate and formative material is dispersed throughout all the tissues of the organism—is sustained by the fact that, both in certain plants and in certain invertebrated animals, a severed portion of the organism will develop into an entire organism similar to that from which it was derived, as, for example, is the case with a leaf of Begonia, and with portions cut from certain invertebrated animals, such as sea-anemones, jelly-fish, &c. This well-known fact in itself seems enough to prove that the formative material in question must certainly admit, at all events in many cases, of being distributed throughout all the tissues of living organisms.

The third assumption—or that which supposes the formative material to be especially aggregated in the sexual elements—is not so much an assumption as a statement of obvious fact; while the fourth, fifth, sixth, and seventh assumptions all follow deductively from their predecessors. In other words, if the first and second assumptions be granted, and if the theory is to comprise all the facts of heredity, then the remaining five assumptions are bound to follow.

To the probable objection that the supposed gemmules must be of a size impossibly minute—seeing that thousands of millions of them would have to be packed into a single ovum or spermatozoon—Darwin opposes a calculation that a cube of glass or water, having only one ten-thousandth of an inch to a side, contains somewhere between sixteen and a hundred and thirty-one billions of molecules. Again, as touching the supposed power of multiplication on the part of his gemmules, he alludes to the fact that infectious material of all kinds exhibits a ratio of increase quite as great as any that his theory requires to attribute to gemmules. Furthermore, with respect to the elective affinity of gemmules, he remarks that “in all ordinary cases of sexual reproduction, the male and female elements certainly have an elective affinity for each other”: of the ten thousand species of Compositae, for example, “there can be no doubt that if the pollen of all these species could be simultaneously placed on the stigma of any one species, this one would elect, with unerring certainty, its own pollen.”

Such, in brief outline, is Mr. Darwin’s theory of Pangenesis.

Professor Weismann’s theory of Germ-plasm is fundamentally based upon the great distinction, in respect of their transmissibility, between characters that are congenital and characters that are acquired. By a congenital character is meant any individual peculiarity, whether structural or mental, with which the individual is born. By an acquired character is meant any peculiarity which the individual may subsequently develop in consequence of its own individual experience. For example, a man may be born with some malformation of one of his fingers; or he may subsequently acquire such a malformation as the result of accident or disease. Now, in the former case—i.e., in that where the malformation is congenital—it is extremely probable that the peculiarity will be transmitted to his children; while in the latter case—i.e., where the malformation is subsequently acquired—it is virtually certain that it will not be transmitted to his children. And this great difference between the transmissibility of characters that are congenital and characters that are acquired extends universally as a general law throughout the vegetable as well as the animal kingdom, and in the province of mental as in that of bodily organization. Of course this general law has always been well known, and more or less fully recognized by all modern physiologists and medical men. But before the subject was taken up by Professor Weismann, it was generally supposed that the difference in question was one of degree, not one of kind. In other words, it was assumed that acquired characters, although not so fully—and therefore not so certainly—inherited as congenital characters, nevertheless were inherited in some lesser degree; so that if the same character continued to be developed successively in a number of sequent generations, what was at first only a slight tendency to be inherited would become by summation a more and more pronounced tendency, till eventually the acquired character might be as strongly inherited as any other character which was ab initio congenital. Now it is the validity of this assumption that is challenged by Professor Weismann. He says there is no evidence of any acquired characters being in any degree inherited; and, therefore, that in this important respect they may be held to differ from congenital characters in kind. On the supposition that they do thus differ in kind, he furnishes a very attractive theory of heredity, which serves at once to explain the difference, and to represent it as a matter of physiological impossibility that any acquired character can, under any circumstances whatsoever, be transmitted to progeny.

But, in order fully to comprehend this theory, it is desirable first of all to explain Professor Weismann’s views upon certain other topics which are intimately connected with—and, indeed, logically sequent upon—the use to which he puts the distinction just mentioned.

Starting from the fact that unicellular organisms multiply by fission and gemmation, he argues that, aboriginally and potentially, life is immortal. For when a protozoon divides itself into two more or less equal parts by fission, and each of the two halves thereupon grows into another protozoon, it does not appear that there has been any death on the part of the living material involved; and inasmuch as this process of fission goes on continuously from generation to generation, there is seemingly never any death on the part of such protoplasmic material, although there is a continuous addition to it as the numbers of individuals increase. Similarly, in the case of gemmation, when a protozoon parts with a small portion of its living material in the form of a bud, this portion does not die, but develops into a new individual; and, therefore, the process is exactly analogous to that of fission, save that a small instead of a large part of the parent substance is involved. Now, if life be thus immortal in the case of unicellular organisms, why should it have ceased to be so in the case of multicellular? Weismann’s answer is, that all the multicellular organisms propagate themselves, not exclusively by fission or gemmation, but by sexual fertilization, where the condition to a new organism arising is that minute and specialized portions of two parent organisms should fuse together. Now, it is evident that with this change in the method of propagation, serious disadvantage would accrue to any species if its sexual individuals were to continue to be immortal; for in that case every species which multiplies by sexual methods would in time become composed of individuals broken down and decrepit through the results of accident and disease—always operating and ever accumulating throughout the course of their immortal lives. Consequently, as soon as sexual methods of propagation superseded the more primitive a-sexual methods, it became desirable in the interests of the sexually-propagating species that their constituent individuals should cease to be immortal, so that the species should always be recuperated by fresh, young, and well-formed representatives. Consequently, also, natural selection would speedily see to it that all sexually-propagating species should become deprived of the aboriginal endowment of immortality, with the result that death is now universal among all the individuals of such species—that is to say, among all the metazoa and metaphyta. Nevertheless, it is to be remembered that this destiny extends only to the parts of the individual other than the contents of those specialized cells which constitute the reproductive elements. For although in each individual metazoon or metaphyton an innumerable number of these specialized cells are destined to perish during the life, or with the death, of the organism to which they belong, this is only due to the accident, so to speak, of their contents not having met with their complements in the opposite sex: it does not belong to their essential nature that they should perish, seeing that those which do happen to meet with their complements in the opposite sex help to form a new living individual, and so on through successive generations ad infinitum. Therefore the reproductive elements of the metazoa and metaphyta are in this respect precisely analogous to the protozoa: potentially, or in their own nature, they are immortal; and, like the protozoa, if they die, their death is an accident due to unfavourable circumstances. But the case is quite different with all the other parts of a multicellular organism. Here, no matter how favourable the circumstances may be, every cell contains within itself, or in its very nature, the eventual doom of death. Thus, of the metazoa and metaphyta it is the “germ-plasms” alone that retain their primitive endowment of everlasting life, passed on continuously through generation after generation of successively perishing organisms.

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