wunder betaðŸâ€Â„ The Krebs cycle, step by step
Follow acetyl-CoA through carbon loss, electron capture, substrate-level phosphorylation, and oxaloacetate regeneration.
What you’ll learn
- Set the stage
- Entry reaction
- Rearrange the substrate
- First oxidation
- Second oxidation
- Substrate-level phosphorylation
- Regenerate the acceptor
- Hydrate the double bond
- Close the loop
- Count one turn
- Connect to respiration
- Use intermediates
- Study the sequence
- Check the model
- Exam synthesis
Questions this course answers
What molecule is regenerated at the end of the cycle?
Malate oxidation produces oxaloacetate, the four-carbon acceptor needed for the first step.
Which carriers are produced by cycle oxidations?
Dehydrogenase steps transfer electrons to NAD+ or FAD, producing NADH or FADH2.
How many turns occur per glucose?
One glucose yields two pyruvate-derived acetyl-CoA molecules, so the cycle turns twice.
Which step makes GTP or ATP directly?
Succinyl-CoA synthetase performs substrate-level phosphorylation.
Why can oxygen be required indirectly?
The cycle depends on regenerated NAD+ and FAD, which aerobic respiration supports through oxygen's terminal electron acceptance.
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