CHAPTER VIII

AVITAMINOSES OR THE DISEASES THAT RESULT FROM VITAMINE DEFICIENCIES

A survey of the vitamines would be incomplete without a discussion of the vitamine deficiency diseases in particular, though many of the facts already cited obviously bear on the treatment and prevention of such diseases.

The idea of "avitaminoses" or vitamine deficiency as the cause of a disease of a specific nature was set forth in detail by Funk in his book Die Vitamine. In his discussion of this view he suggests several types that would, he felt, on examination prove to be due to the absence of a vitamine in the diet. Of these predicted types beri-beri was the only one to be established in 1913. Scurvy has now been added to the fold and rickets or rachitis seems well on the way to acceptance though the specific vitamine absent in this case is not yet positively identified. Pellagra still resists the efforts of the vitamine hypothesis to bend it to that theory and its etiology is still obscure.

I. BERI-BERI

This disease while specifically confined to the oriental in the mind of the student can be justly considered of much wider distribution for the mild forms of malnutrition associated with a deficiency in the "B" vitamine are less acute manifestations of this disease. The disease is not likely to become marked in well nourished districts in its acute form, but in famine districts its incidence is always possible. It would be more than possible were it not for the fact that famine tends to eliminate the highly milled cereals and throw the people back on to the whole grain, peas and beans, which are rich in the preventive factor. But when for any reason diets become limited extra attention is demanded in regard to their selection and preparation. The main characteristics of this disease have already been fully covered in what precedes and need not be repeated here.

II. SCURVY

This disease, like beri-beri has already been fully discussed in what precedes. One of the striking discoveries of this subject has been the retreat from favor of the time-honored lime juice which is now found to be much less potent than oranges, lemons, or even canned tomato juice and which on preservation loses practically all its potency. In the modern hospital, cases of scurvy rarely appear outside of occasional infant cases and it might appear that the problem of scurvy prevention is peculiarly that of the sailor, the explorer and the army rationer. Nevertheless an insufficient supply of the "C" vitamine may retard growth and well being in the individual without manifesting itself in its more acute form of scurvy. In a recent review Hess states: "It is hardly an exaggeration to state that in the temperate zones the development or non-development of scurvy depends largely on the potato crop." "This is attributed in part to the fact that the potato is an excellent antiscorbutic, but to a greater extent because it is consumed during the winter in amounts that exceed the combined total of all other vegetables." To the public and to the food purveyor there is a definite problem in how to best supply the preventive and how best to concentrate and preserve the sources of this vitamine without injury to its potency. The following observation is therefore appended as bearing on this point. In the absence of fruits or other high potency sources it is possible to develop this factor in cereal grains by the simple expediency of sprouting. If seeds are soaked in water for twenty-four hours and then kept moist for from one to three days with the free access of air, sprouts will develop whose content of the antiscorbutic vitamine is comparable to that of many fresh vegetables, even though the dry seeds themselves have little of this factor. In other words the germination process is a synthesiser of the vitamine. This observation may be of value where fruits and vegetables are scarce or expensive. On account of cooking effects, it cannot be too often reiterated that raw fruits, vegetables and salads, are of more value than cooked forms of these same sources and that drying processes are extremely destructive where heat enters into the drying process. Vacuum drying seems to be much less destructive and it may be possible to develop the drying of vegetables to a point where retention of this vitamine factor is practical. At present all dried vegetables should be regarded with suspicion as a source of vitamine "C." Expressed juices may often be used where the whole vegetable is scarce or incompatible and this fact is one to be borne in mind by the worker in famine districts.

III. RACHITIS (RICKETS)

This disease is engaging the attention of many workers on both sides of the Atlantic at the present time. In England the principal contributor is Dr. Mellanby, who has accumulated evidence which he believes indicates that the preventive factor is the A vitamine. This view is not yet accepted as conclusive by the American workers. McCollum, Howland, Park, and others at Johns Hopkins University have experimented with various rickets-producing diets and while the principal deficiency in these diets seems to be Ca salts and the A vitamine they do not consider that the disease can as yet be traced to deficiency in any one factor. Hess has called attention to several new features and the significance of some older measures. He has shown on the one hand that cod-liver oil is almost a specific remedy for the disease but that this remedy is not replaceable by other rich sources of the A vitamine. He has also recently shown that hygienic measures may have an influence. Schmorl showed that the disease was seasonal, a high rate maintaining in the winter months and a lower rate in the summer months. Hess has recently reported beneficial results from use of the ultra-violet rays which he uses as a substitute for sunlight. The results seem to confirm Schmorl's view that the sunlight of the summer months is a preventive factor. He has also suggested that the specific effect of the cod-liver oil might be due to a new vitamine, Vitamine D? On the other hand Zilva and Miura in England have recently shown that crude cod-liver oil is something like two hundred and fifty times as rich in vitamine A as butter fat, which tends to support the British view that the A vitamine is the antirachitic factor.

Sherman and Pappenheimer have recently shown that the phosphates exert a marked preventive effect on rickets and suggest that the utilization of the calcium by the individual may be determined in part by this factor.

The views in brief are now in an extremely chaotic state and it is impossible at present to determine whether rickets is a true avitaminose or a consequence of deficiency in a series of factors. It is however certain that the disease in its subacute forms is extremely wide-spread among infants and that its prevention can be most easily secured by the addition of cod-liver oil to the diet. In this procedure warning is necessary that the cod-liver oil be as pure a product of oil as possible, since the market preparations are often almost devoid of the true oil and hence of the curative agent.

IV. PELLAGRA

This disease has been the subject of exhaustive inquiry and study on this side of the Atlantic and the findings of the various investigating boards have added much to the prevention and cure of the scourge, but have failed as yet to agree on any one etiological factor. The best recent review of the current findings is to be found in an article by Voegtlin published as Reprint 597 of the Public Health Reports of the United States Public Health Service. His conclusions may be quoted in full as representing the latest summary of evidence now extant:

1. The hypothesis that there is a causal relation between pellagra and a restricted vegetable diet has been substantiated by direct proof to this effect and has led to results of considerable practical and scientific value.

2. The metabolism in pellagra shows certain definite changes from the normal, which point to decreased gastric secretion and increased intestinal putrefaction.

3. In the treatment and prevention of pellagra, diet is the essential factor. The disease can be prevented by an appropriate change in diet without changing other sanitary conditions.

4. A diet of the composition used by pellagrins prior to their attack by the disease leads to malnutrition and certain pathological changes in animals, resembling those found in pellagra. A typical pellagrous dermatitis has not been observed in animals. Pellagrous symptoms have been produced in man by the continued consumption of a restricted vegetable diet.

5. The nature of the dietary effect has not been discovered, although certain observations point to a combined deficiency in some of the recognized dietary factors as the cause of the pellagrous syndrome.

In elaborating on conclusion 5 Voegtlin states that:

The conception that pellagra is due to a dietary deficiency is, therefore, not contradicted by the available evidence. This does not imply that the disease is necessarily due to a deficiency of diet in a specific substance such as the hypothetical pellagra vitamine of Funk (1913). It is much more likely that the pellagrous syndrome is caused by a combination of the deficiencies in some of the well recognized food factors.

V. OTHER AVITAMINOSES

The rôle of the vitamine in the nutrition and growth of organisms other than the man is becoming a matter of interest in various ways. The construction of culture media for various strains of bacteria and the conditions favorable or unfavorable to their growth, are features of study in which the new hypothesis has demanded attention. It has already been claimed that vitamines are essential to the growth of the meningococcus, the influenza bacillus, the typhoid bacillus, the gonococcus, the pneumococcus Type I, Streptococcus hemolyticus, the diptheria bacillus, the Bacillus pertussis and certain soil organisms. If these views are confirmed it becomes evident that the means for prevention of the development of these forms may lie in the control of the vitamine content of the materials on which these forms thrive and that in the study of these types it may be possible to speed up the incubation of strains and thus hasten diagnostic measures by introducing the necessary vitamines into the culture media. These observations merely suggest the possible widening of the scope of the vitamine study in the service of man and give added reason for our keeping pace with the strides made in this particular field.

BIBLIOGRAPHY

ABDERHALDEN, E., AND LAMPE, A. E.: Z. ges. exp. Med., (1913), i, 296.

ABDERHALDEN, E., AND SCHATJMANN: Beitrag zur Kenntnis von organischer Nahrungsstoffen mit spezifischer Wirkung I. Pflüger's Archiv. f. d. ges. Physiol., (1918), clxxii, 1.

ABDERHALDEN, E.: Weitere Beitrage zur Kenntnis von organischen Nahrungsstoffen mit spezifischer Wirkung II. Pfülger's Archiv. f. d. ges. Physiol., (1920), clxxviii, 133.

ABDERHALDEN, E.: Weitere Beitrage zur Kenntnis von organischen Nahrungsstoffen mit spezifischer Wirkung III. Pflüger's Archiv. f. d. ges. Physiol., (1920), clxxviii, 260.

ABELS, H.: Wiener klinische Wochenschr., (1920), xxxiii, 899.

ABEL, J. J., AND KUBOTA, S.: On the presence of histamine in the hypophysis cerebri and other tissues of the body and its occurrence among the hydrolytic decomposition products of proteins. J. Pharmacol. and Exp. Therap., (1919), xiii, 243.

AGULHON AND LEGROUX: Contribution a l'etude des vitamines utilisable a la culture des micro-organismes; application au bacille de l'influenza B. de Pfeiffer. Compt. rend. Acad. de Sc. Paris, (1918), clxvii, 597.

ALWENS: Osteoporosis and osteomalacia. Munch. med. Woch., (1919), lxvi, 1071.

ANDREWS: Infantile beri-beri. Phil. J. Sci., (1911), vi, B, 67.

ANGREP, G. V., AND DRUMMOND, J. C.: Note on the supposed identity of water soluble vitamin B and secretin. J. Physiol., 1921, liv, 349.

ARON, H.: Phosphorus starvation with special reference to beri-beri. Ph. Journ. Sci., (1910), v, B, 81.

ARON, H., AND HOCSON: Ibid., Phil. J. Sci., 1910, v, B, 98.

ARON, H.: Ueber der "Nahrwert" und die Bedeutung der Nahrungsfette. Biochem. Ztschr., (1920), ciii, 172.

BACHMAN, FREDA: Vitamine requirements of certain yeasts. J. Biol. Chem., 1919, xxxix, 235.

BARLOW, T.: Meat juice for infants as antiscorbutic. Lancet, London, 1894, ii, 1075.

BARNES, R. E., AND HUME, E. M.: Comparison between the antiscorbutic properties of fresh, heated, and dried cow's milk. Lancet, London, 1919, ii, 323.

BARNES, R. E., AND HUME, E. M.: Relative antiscorbutic value of fresh, dried and heated cow's milk. Biochemical J., 1919, xiii, 306.

BASSETT-SMITH, P. W.: Preservation of lemon juice. Lancet, London, 1920, ii, 997.

BASSETT-SMITH, P. W.: Scurvy. Lancet, London, 1920, i, 1102.

BOTTOMLEY, W. B.: Some accessory factors in plant growth and nutrition. Proc. Roy. Soc. London, 1914, Series ii, lxxxviii, 237, and lxxxix, 102 and 481.

BLUNT, K., AND WANG, CHI CHE: The present status of vitamines. J. Home Econ., 1921, xxii, 97.

BRADDON, W. L.: Causes and prevention of beri-beri, London, 1907.

BRADDON, W. L., AND COOPER, E. L.: The influence of the total fuel value of a dietary upon the quantity of vitamine required to prevent beri-beri. British Med. J., London, 1914, 1348.

BREUER, M.: Oedemes de guerre. Bull. l'acad. roy. med. belgique, 1920, xxx, 31 and 99.

BRITISH MEDICAL RESEARCH COMMITTEE: Report on the present state of knowledge concerning accessory food factors. H. M. Stationery Office, Imperial House Kingsway, London, W. C. 2.

BRUNTZ, L., AND SPILLMAN, L.: Compt. rend. Soc., biol., 1919, lxxxii, 8.

BULLEY, E. C.: Note on Xeropthalmia in rats. Biochem. J., 1919, xiii, 103.

BYFIELD, A. H., DANIELS, A. L., AND LOUGHLIN, R.: The antineuritic and growth stimulating properties of orange juice. Am. J. Dis. of Chil., 1920, xix, 349.

CAMPBELL, M. E. D., AND CHICK, H.: The antiscorbutic and growth-promoting value of canned vegetables. Lancet, London, 1919, ii, 320.

CAJORI, F. A.: The nutritive value of some nuts. Proc. Soc. Exp. Biol. and Med., 1920, xvii, 78.

CAJORI, F. A.: Some nutritive properties of nuts, their proteins and content of water-soluble vitamine. J. Biol. Chem., 1920, xliii, 583.

CHAMBERLAIN: The eradication of beri-beri from the Philippine Scouts by means of a simple change in the dietary. Ph. J. of Sci., 1911, vi, B, 133.

CHAMBERLAIN, BLOOMBERGH AND KILBOURNE: A study of the influence of rice diet and of inanition on the production of multiple neuritis in fowls. Ph. J. of Sci., 1911, vi, B, 172.

CHAMBERLAIN AND VEDDER: A contribution to the etiology of beri-beri. Ph. J. of Sci., 1911, vi, B, 251.

CHAMBERLAIN AND VEDDER: A second contribution to the etiology of beri- beri. Ph. J. of Sci., 1911, vi, B. 395.

CHAMBERLAIN, VEDDER AND WILLIAMS: A third contribution to the etiology of beri-beri. Ph. J. of Sci., 1912, vii, B, 39.

CHICK, H., AND MARTIN, C. J.: On the heat coagulation of proteins. J. Physiol., 1910, xl, 404.

CHICK, H.: J. Hyg., 1910, x, 237.

CHICK, H., AND HUME, E. M.: Tr. Soc. Trop. med. u. Hyg., 1916-17, x, 141, 156, 179.

CHICK, H., AND HUME, E. M.: The distribution among food stuffs (especially those suitable for the rationing of armies) of the substances required for the prevention of (a) beri-beri and (b) scurvy. J. Roy. Arm. Med. Corps., 1917, xxix, 121.

CHICK, H., AND HUME, E. M.: The distribution in wheat, rice and maize grains of the substance the deficiency of which in a diet causes polyneuritis in birds and beri-beri in man. Proc. Roy. Soc., 1917. xc, B, 44.

CHICK, H., AND HUME, E. M.: The effect of exposures to temperatures at or above 100° C. upon the substance whose deficiency in the diet causes polyneuritis in birds and beri-beri in man. Proc. Roy. Soc. London, 1917- 18, Series B, xc, 60.

CHICK, H., HUME, E. M., AND SKELTON, R. F.: An estimate of the antiscorbutic value of milk in infant feeding. Lancet, London, 1918, i, 1.

CHICK, H., AND SMITH, A.: The relative content of antiscorbutic principle in lemons and limes. Lancet, London, 1918, ii, 735.

CHICK, H., AND RHODES, M.: An investigation of the antiscorbutic value of the raw juices of root vegetables. Lancet, London, 1918, ii, 774.

CHICK, H., HUME, E. M., AND SKELTON, R. F.: The antiscorbutic value of cow's milk. Biochem. J., 1918, xii, 131.

CHICK, H., AND HUME, E. M.: Note on the importance of accurate and quantitative measurements in experimental work on nutrition and accessory food factors. J. Biol. Chem., 1919, xxxix, 203.

CHICK, H., HUME, E. M., AND SKELTON, R. F.: The antiscorbutic value of some Indian dried fruits (tamarind, cocum, and mango). Lancet, 1919, ii, 322.

CHICK, H., AND DELF, E. M.: The antiscorbutic value of dry and germinated seeds. Biochem. J., 1919, xiii, 199.

CHICK, H., AND HUME, E. M.: The production in monkeys of symptoms closely resembling pellagra by prolonged feeding on a diet of low protein content. Biochem. J., 1920, xiv, 135.

CHICK, H., AND DALYELL, E. J.: The present position of vitamines in clinical medicine. Brit. Med. Journ., 1920, ii, 151.

CHICK, H., AND DALYELL, E. J.: The influence of overcooking vegetables in causing scurvy among children. Brit. Med. Journ., 1920, ii, 546.

CHICK, H., AND DALYELL, E. J.: Epidemic of scurvy among children. Z. Kinderheilk, 1920, xxvi, 257.

CHICK, H.: Der Rolle der Vitamine in der Ernahrung. Wiener mod. Woch., 1920, lxx, 411.

CLAIR, F.: Beri-beri experimental. Etiologie du beri-beri. Bull. de la Soc. de pathol. exot., 1920, xiii, 191.

COHEN, B., AND MENDEL, L. B.: Experimental scurvy of the guinea pig in relation to diet. J. Biol. Chem., 1918, xxxv, 425.

COLE AND LLOYD: The preparation of solid and liquid media for the cultivation of the gonococcus. J. Path. and Bacteriol., 1916-17, xxi, 267.

COOPER, E. A., AND FUNK, C.: Experiments on the causation of beri-beri. Lancet, London, 1911, ii, 1266.

COOPER, E. A.: On the protective and curative properties of certain food stuffs. J. Hyg. Cambridge, 1912, xii, 436; and 1914, xiv, 12.

COOPER, E. A.: The nutritional importance of the presence in dietaries of minute amounts of accessory substances. Brit. Med. J. 1913, 722.

COOPER, E. A.: The preparation from the animal tissues of a substance which cures polyneuritis induced in birds by diets of polished rice. Biochem. J., 1913, vii, 268.

COOPER, E. A.: The curative action of autolysed yeast against avian polyneuritis. Biochem. J., 1914, viii, 250.

COOPER, E. A.: The relation of vitamine to lipoids. Biochem. J., 1914, viii, 347.

COPLANS, M.: Tr. Epedemiol. Soc., 1904, xxiii, 1.

CRAMER, W.: Vitamines and lipoid metabolism. Proc. Physiol. Soc., 1920, and J. Physiol., liv, ii-iv.

CROSBY, C. E.: Pellagra with erythema of scrotum as initial skin manifestation. Jour. Am. Med. A., 1917, lxviii, 1403.

DAVIS, D. J.: Food accessory factors in bacterial culture with special reference to hemophilic bacilli I. J. Infect. Dis., 1917, xxi, 392.

DAVIS, M.: Studies in nutrition and observation on vitamine content of foods. J. Home Econ., 1920, xii, 206 and 209.

DANIELS, A., AND NICHOLS: The nutritive value of the soy bean. J. Biol. Chem., 1917, xxxii, 91.

DANIELS, A., AND LOUGHLIN, R.: Feeding experiments with peanuts. J. Biol. Chem., 1918, xxxiii, 295.

DANIELS, A., AND MCCLURG: The influence of high temperatures and dilute alkalies on the antineuritic properties of foods. J. Biol. Chem., 1919, xxxvii, 201.

DANIELS, A., AND LOUGHLIN, R.: Note on the fat-soluble growth promoting substance in lard and cotton seed oil. J. Biol. Chem., 1920, xlii, 359.

DANIELS, A., AND LOUGHLIN, R.: A deficiency in heat treated milks. J. Biol. Chem., 1920, xliv, 381.

DANIELS, A., BYFIELD, A. H., AND LOUGHLIN, R.: The rôle of the antineuritic vitamine in the artificial feeding of infants. Am. J. Dis. Chil., 1919, xviii, 546.

DECAISNE, E.: Gaz. med., 1871, xxvi, 317.

DEGREZ, A., AND BIERRY, H.: Equilibre azote et carence des vitamines. Compt. rend. 1920, clxx, 1209.

DEIACO, P.: Ueber lokalisation und natur der pellagrosen hautsymptome. Wien. klin. Wochenschr., 1907, xx, 967.

DELF, E. M.: The antiscorbutic value of cabbage. I. The antiscorbutic and growth promoting properties of raw and heated cabbage. Biochem. J., 1918, xii, 416.

DELF, E. M., AND SKELTON, R. F.: The antiscorbutic value of cabbage. II. The effect of drying on the antiscorbutic and growth promoting properties of cabbage. Biochem. J., 1918, xii, 448.

DELF, E. M.: The effect of heat on the antiscorbutic accessory factor of vegetable and fruit juices. Biochem. J., 1920, xiv, 211.

DENTON, M., AND KOHMAN: Feeding experiments with raw and boiled carrots. J. Biol. Chem., 1918, xxxvi, 249.

DRUMMOND, J. C., AND FUNK, C.: The chemical investigation of the phosphotungstic precipitate from rice polishings. Biochem. J., 1914, viii, 598.

DRUMMOND, J. C.: Observations upon the growth of chickens under laboratory conditions. Biochem. J., 1916, x, 77.

DRUMMOND, J. C.: The growth of rats upon artificial diets containing lactose. Biochem. J., 1916, x, 89.

DRUMMOND, J. C.: A study of the water-soluble accessory growth promoting substance in yeast. I. Biochem. J., 1917, xi, 255.

DRUMMOND, J. C.: A comparative study of tumour and normal tissue growth. Biochem. J., 1917, xi, 325.

DRUMMOND, J. C.: A study of the water-soluble accessory substance. II. Its influence upon the nutrition and nitrogen metabolism of the rat. Biochem. J., 1918, xii, 25.

DRUMMOND, J. C.: Note on the rôle of the antiscorbutic factor in nutrition. Biochem. J., 1919, xiii, 77.

DRUMMOND, J. C.: Nutrition on diets practically devoid of fats. J. Physiol. 1920, liv, p. xxx, Proc. Physiol. Soc.

DRUMMOND, J. C.: Research on the fat-soluble accessory substance. I. Observations on its nature and properties. Biochem. J., 1919, xiii, 81.

DRUMMOND, J. C.: Research on the fat-soluble accessory substance. II. Observation on its rôle in nutrition and influence on fat metabolism. Biochem. J., 1919, xiii, 95.

DRUMMOND, J. C.: The nomenclature of the so-called accessory food factors. Biochem. J., 1920, xiv, 660.

DRUMMOND, J. C., AND COWARD, K. H.: Researches on the fat-soluble accessory substance. III. Technique. Biochem. J., 1920, xiv, 661.

DRUMMOND, J. C., AND COWARD, K. H.: Researches on the fat-soluble accessory substance. IV. Nuts as a source of vitamine A. Biochem. J., 1920, xiv, 665.

DRUMMOND, J. C., AND COWARD, K. H.: Researches on the fat-soluble accessory substance. V. The nutritive value of animal and vegetable oils and fats considered in relation to their color. Biochem. J., 1920, xiv, 668.

DRUMMOND, J. C., AND COWARD, K. H.: Researches on the fat soluble accessory substance. VI. The effect of heat and oxygen on he nutritive value of butter. Biochem. J. 1920, xiv, 744.

DRUMMOND, J. C., GOLDING, J., ZILVA, S. S., AND COWARD, K. H.: The nutritive value of lard. Biochem. J., 1920, xiv, 742.

DRUMMOND, J. C.: Some aspects of infant feeding. Lancet, London, 1918, ii, 482.

DUBIN, H. E., AND LEWI, M. J.: A stable vitamine product. Amer. J. Med. Sci., 1920, clix, 362.

DUBIN, H. E.: The preparation of a stable vitamine product and its value in nutrition. Science, li, 71, 1920.

DURAND, J. I.: The influence of diet on the development and health of the teeth. J. Am. Med. Assn., 1916, lxvii, 564.

DUTCHER, R. A.: Vitamine Studies. I. Observations on the catalase activity of tissues in avian polyneuritis. J. Biol. Chem., 1918, xxxvi, 63.

DUTCHER, R. A., AND COLLATZ: Vitamine Studies. II. Does water-soluble vitamine function as a catalase activator. J. Bio. Chem., 1918, xxxvi, 547.

DUTCHER, R. A.: Vitamine Studies. III. Observations on the curative properties of honey, nectar and corn pollen in avian polyneuritis. J. Biol. Chem., 1918, xxxvi, 551.

DUTCHER, R. A.: Vitamine Studies. IV. Antineuritic properties of certain physiological stimulants. J. Biol. Chem., 1919, xxxix, 63.

DUTCHER, R. A., PARSONS, E. M., AND BIESTER, A.: The antiscorbutic properties of raw lean beef. Science, 1919, l, 184.

DUTCHER, R. A., PIERSON, E. M., AND BIESTER, A.: Vitamine Studies. V. The antiscorbutic properties of raw beef. J. Biol. Chem., 1920, xlii, 301.

DUTCHER, R. A., DAHLE, C. D., ECKELS, C. H., MEAD, S. W., AND SCHAEFFER, 0. G.: Vitamine Studies. VI. The influence of the diet of the cow upon the nutritive and antiscorbutic properties of milk. J. Biol. Chem., 1920, xlv, 119.

DUTCHER, R. A.: The nature and function of the antineuritic vitamine. Proc. Natl. Acad. Sci., vi, 10 (1920).

DUTCHER, R. A., AND PIERSON, E. M.: Rhubarb as an antiscorbutic. Science, li, 70 (1920).

DUTCHER, R. A., KENNEDY, C., AND ECKELS, C. H.: The influence of the diet of the cow upon the fat-soluble and water-soluble vitamines of cow's milk. Science lii, 588 (1920).

DYKE, H. W.: Outbreak of scurvy in the S. African Native Labour Corps. Lancet, London, 1918, ii, 513.

EDDY, W. H.: The isolation of a growth producing substance from sheep pancreas. J. Biol. Chem., 1916, xxvii, 113.

EDDY, W. H., AND STEVENSON, H. C.: Studies in the vitamine content. J. Biol. Chem., 1920, xliii, 295.

EDDY, W. H., AND ROPER, J. C.: The use of pancreatic vitamine in marasmus. Am. J. Dis. Children, 1917, xiv, 189.

EDDY, W. H., AND ROPER, J. C.: The use of pancreatic vitamine in cases of infant malnutrition. Proc. Soc. Exp. Biol. and Med., 1916, xiv, 52.

EDDY, W. H., AND CALKINS, G. N.: The action of pancreatic vitamine on the metabolic activity of paramecium. Proc. Soc. Exp. Biol. and Med., 1917, xiv, 162.

EDDY, W. H.: Further observations on pancreatic vitamine. Proc. Soc. Exp. Biol. and Med., 1917, xiv, 164.

EDDY, W. H., AND STEVENSON, H. C.: The suitability of the Bachman test for water-soluble B. Proc. Soc. Exp. Biol. and Med., 1919, xvii, 52.

EDDY, W. H., AND STEVENSON, H. C.: Some results with a new technique in vitamine measurement, 1920, xvii, 268.

EDDY, W. H., HEFT, H. L., STEVENSON, H. C., AND JOHNSON, R.: The yeast test as a measure of vitamine content. Proc. Soc. Exp. Biol. and Med. 1921, xviii, 138.

EDDY, W. H.: Further studies of the use of water-soluble vitamine in the treatment of infant malnutrition. J. Biol. Chem., 1920, xli, p. xxxiv Proc.

EDDY, W. H.: The Vitamines--a bibliographic review. Abstr. Bacteriol., 1919, iii, 313.

EDIE, E. S., AND SIMPSON, G. C. E.: Annals Trop. Med. and Parsitol. 1911, v, 313.

EDIE, E. S., EVANS, W. H., MOORE, B., SIMPSON, G. C. E., AND WEBSTER, A.: The antineuritic bases of vegetable origin in relationship to beri-beri with a method of isolating torulin, the antineuritic base of yeast. Biochem. J., 1912, vi, 234.

EIJKMAN: Eine beri-beri-aehnliche Krankheit der Huehner. Arch. f. path. anat. Berlin, 1897, cxlviii, 523.

EIJKMAN: Arch. f. Hyg. Munchen. u. Berlin, 1906, lviii, 150.

EMMETT, A. D., AND MCKIM: The value of the yeast vitamine factors as a supplement to rice diet. J. Biol. Chem., 1917, xxxii, 409.

EMMETT, A. D., AND LUROS, G. 0.: The stability of lactalbumin toward heat. J. Biol. Chem., 1919, xxxviii, 257.

EMMETT, A. D., AND ALLEN, F. P.: Nutritional studies on the growth of frog larvae. J. Biol. Chem., 1919, xxxviii, 325.

EMMETT, A. D., AND LUROS, G. O.: The absence of fat soluble A vitamine in certain ductless glands. J. Biol. Chem., 1919, xxxviii, 441.

EMMETT, A. D., ALLEN, F. P., AND STURTEVANT, M.: Relation of vitamine and iodine to the size and development of the tadpole. J. Biol. Chem., 1920, xli, p. liv; Proc.

EMMETT, A. D., AND LUROS, G. 0.: Are the antineuritic and water-soluble B vitamines the same? J. Biol. Chem., 1920, xli, p. vii, Proc.

EMMETT, A. D., AND ALLEN, F. P.: Pathogenesis due to vitamine deficiency in the rat. J. Biol. Chem., 1920, xli, p. liii, Proc.

EMETT, A. D., AND LUROS, G. O.: Water-soluble vitamine I. Are the antineuritic and growth promoting water-soluble B the same? J. Biol. Chem., 1920, xliii, 265.

EMETT, A. D., AND STOCKHOLM, M.: Water-soluble vitamines. II. The relation of antineuritic and water-soluble B vitamines to the yeast growth promoting stimulus. J. Biol. Chem., 1920, xliii, 287.

EMETT, A. D.: The fat-soluble A vitamine in Xerophthalmia. Science, 1920, lii, 157.

ERIGHT, J. I.: Pellagra outbreak in Egypt. Lancet, London, 1920, i, 998.

FABER, H. K.: A study of the antiscorbutic value of honey. J. Biol. Chem. 1920, xliii, 113.

FABER, H. K.: Sodium citrate and scurvy. Proc. Soc. Exper. Biology and Med., 1920, xvii, 140.

FAMULENER, L. W., AND MAASEN, TH.: Biochem. Ztschr., 1909, xi, 186.

FERRY, EDNA L.: Nutrition experiments with rats. J. Lab. and Clin. Med., 1920, v, 735.

FRASER AND STANTON: On the etiology of beri-beri. Phil. J. of Sci., 1920, V, B, 55.

FRASER AND STANTON: The cause of beri-beri. Lancet, London, 1910, 733.

FRASER AND STANTON: The cause of beri-beri. Lancet, London, 1910, ii, 1755.

FURST: Experimental scurvy. Ztschr. f. Hyg. u. Infekstionskrankh., Leipzig, 1912, lxxii, 121.

FULMER, E. I., NELSON, V. E., AND SHERWOOD, F. F.,: Nutritional requirement of yeast. I. The rôle of vitamines in the growth of yeast. J. Am. Chem. Soc., 1921, xliii, 186.

FULMER, E. I., NELSON, V. E., AND SHERWOOD, F. F.: Nutritional requirement of yeast. II. The effect of the composition of the medium on the growth of the yeast. J. Am. Chem. Soc., 1921, xliii, 191.

FUNK, C.: Ztschr. f. physiol. Chem. Strassburg, 1910, lxix, 72.

FUNK, C.: On the chemical nature of the substance that cures polyneuritis in birds induced by a diet of polished rice. J. Physiol., 1911, xliii, 395.

FUNK, C.: The preparation from yeast and certain food stuffs of the substance, the deficiency of which occasions polyneuritis in birds. J. Physiol., 1912-1913, xlv, 75.

FUNK, C.: The action of certain purine and pyrimidine derivatives. J. Physiol., 1912-13, xlv, 489.

FUNK, C.: Studien ueber Wachstum. Zeitschr. f. physiol. chem. Strassb., 1913, lxxxviii, 352.

FUNK, C.: Studies on beri-beri. The chemistry of the vitamine fractions from yeast and rice polishings. J. Physiol., 1913, xlvi, 173.

FUNK, C.: The nitrogenous constituents of lime juice. Biochem. J., 1913, vii, 81.

FUNK, C.: An attempt to estimate the vitamine fraction in milk. Biochem. J., 1913, vii, 211.

FUNK, C.: Pellagra and Growth. Proc. Roy. Soc. Med., London, (Ther. and Pharm. Sec.), 1913-14, vii, 9.

FUNK, C., AND DOUGLASS, M. J.: J. Physiol., 1913-14, xlvii, 475.

FUNK, C., AND MACALLUM, A. B.: On the chemical nature of substances from alcoholic extracts of various food stuffs which give a color reaction with phosphotungstic and phosphomolybdic acids. Biochem. J., 1913, vii, 356.

FUNK, C., AND SCHONBORN: The influence of vitamine free diet upon carbohydrate metabolism. J. Physiol., 1914, xlviii, 328.

FUNK, C.: Studien ueber beri-beri Ztschr. f. physiol. chem. Strassb., 1914, lxxxix, 373.

FUNK, C., AND MACALLUM, A. B.: Die chemischen Determinaten der Wachstums. Ztschr. f. physiol. Chem. Strassb., 1914, xcii, 13.

FUNK, C.: Die Vitamines, Wiesbaden, 1914 Bergmann.

FUNK, C.: Prophylaxie u. Therapie der Pellagra im Lichte der Vitamin Lehre. Muchen med. Wochenschr., 1914, lxi, 698.

FUNK, C., AND MACALLUM,: Studies on Growth. II. On the probable nature of the substance promoting growth in young animals. J. Biol. Chem., 1915, xxiii, 413.

FUNK, C.: Results of studies on vitamines and deficiency diseases and the biochemistry of cod liver oil. Biochem. Bull., 1916, iv, 306 and 365.

FUNK, C.: The fractioning of the phosphotungstic precipitate. Biochem. Bull., 1916, v, 1.

FUNK, C.: The nature of the disease due to the exclusive diet of oats in guinea pigs and rabbits. J. Biol. Chem., 1916, xxv, 409.

FUNK, C.: A study of certain dietary conditions bearing on the problem of growth in rats. J. Biol. Chem., 1916, xxviii, 1.

FUNK, C., and MACALLUM: Studies on growth. III. The comparative value of lard and butter fat in growth. J. Biol. Chem., 1916, xxvii, 51.

FUNK, C., LYLE AND MCCASKEY: The nutritive value of yeast, polished rice and white bread as determined by experiments on man. J. Biol. Chem., 1916, xxvii, 173.

FUNK, C.: Proc. Soc. Exp. Biol. and Med., 1916-17, xiv, 9.

FUNK, C., and DUBIN, H. E.: A test for anti-beriberi vitamine and its practical application. J. Biol. Chem., 1920, xliv, 487.

FUNK, C., AND DUBIN, H. E.: Vitamine requirements of rats on diets rich in protein, carbohydrates and fat respectively. Science, lii, 447.

FUNK, C.: Action of the substances influencing the carbohydrate metabolism in experimental beri-beri. J. Physiol., 1919, liii, 247.

GAGLIO, G.: La Vori originali Pusenza nelle urine delle cosi dette vitamine. Policlinico, 1919, xxvi, Sezione Pratica, 1381.

GIBSON: The influence of compensated salt substances in the development of the polyneuritis gallinarum and beri beri. Ph. J. of Sci., 1913, viii, B, 351.

GIBSON AND CONCEPCION: Nerve degeneration in fowls fed on polished rice. Ph. J. of Sci., 1914, ix, B, 119.

GIBSON: The protective power of normal human milk against polyneuritis gallinarum. Ph. J. of Sc., 1913, viii, B, 469.

GIORGI, E.: Epidemic Scurvy. Pediatria, Naples, xxix, 66.

GIVEN, M. H., AND COHEN, B.: The antiscorbutic property of desiccated and cooked vegetables. J. Biol. Chem., 1918, xxxvi, 127.

GIVENS, M. H., AND MCCLUGGAGE, H. B.: The antiscorbutic properties of fruits. I. An experimental study of dried orange juice. Am. J. Dis. Chil., 1919, xviii, 30.

GIVENS, M. H., AND MCCLUGGAGE, H. B.: The antiscorbutic properties of vegetables. I. An experimental study of raw and dried tomatoes. J. Biol. Chem., 1919, xxxvii, 253.

GIVENS, M. H., AND MCCLUGGAGE, H. B.: Influence of temperature on the antiscorbutic vitamine in tomatoes. J. Biol. Chem., 1920, xli, p. xxiv Proc.

GIVENS, M. H., AND HOFFMAN, G. L.: Preliminary observations on the relation of bacteria to experimental scurvy in guinea pigs. J. Biol. Chem., 1920, xli, p. xxxiii, Proc.

GIVENS, M. H., AND MCCLUGGAGE, H. B.: Antiscorbutic properties of vegetables. II. An experimental study of raw and dried potatoes. J. Biol. Chem., 1920, xlii, 491.

GIVENS, M. H., AND MCCLUGGAGE, H. B.,: The antiscorbutic properties of dehydrated meat. Science, 1920, li, 273.

GOLDBERGER, J. The transmissibility of pellagra. Pub. Health Rep. U. S., 1916, xxxi, 3159.

GOLDBERGER, J.: Pellagra, causation and a method of prevention. J. Am. Med. Assn., 1916, lxvi, 471.

GOLDBERGER, J., AND WHEELER, G. A.: I. Experimentally produced pellagra in human subjects by means of diet. Bull. 120, 1920, U. S. P. H. Hyg. Lab.

GOLDBERGER, J., WHEELER, G. A., AND SYDENSTRICKER, E.: Pellagra U. S. P. H. Rep., 1920, xxv, 648, 1650, 1701.

GOLDBERGER, J.: Pellagra in Egypt. Lancet, London, 1920, ii, 41.

GOLDBERGER, J., WARING, C. H., AND WILLETTS, D. G.: The prevention of pellagra. U. S. P. H. Reports, 1915, xxx, 3117.

GOLDBERGER, J., AND WHEELER, G. A.: Experimental pellagra in the human subject. U. S. P. H. Reports, 1915, xxx, 3336.

GOLDBERGER, J., WHEELER, G. A., AND SYDENSTRICKER, E.: A study of the diet of pellagrous and non-pellagrous households. J. Am. Med. Assn., 1918, lxxi, 944.

GORDON, HINE AND FLACK: An experimental study of the cultural requirements of the meningococcus. Brit. Med. J., London, 1916, 678.

GREEN, H. H.: 1. Antineuritic hormone. 2. Maize vitamine. So. African J. Sci., 1918, xiv, 483, 519.

GREEN, H. H.: The deficiency aspect of maize products. 5th and 6th Reports of Vet. Res. Dept. Agric. Union S. Africa, Apr., 1918.

GREEN, H. H.: The quantitative relation between the antineuritic value of a diet and the onset of polyneuritis. 5th and 6th Reports of Vet. Res. Dept. Agric. Union S. Africa, Apr. 1918.

GREEN, H. H., AND VILJOEN, P. R.: Contribution to the study of deficiency disease in special reference to the Lamziekte problem in South Africa. 3rd and 4th Reports Div. Vet. Res. Dept. Agric. Union S. Africa, 1918.

GREIG, E. D. W.: The sprouting capacity of grains issued as rations to troops. Indian J. Med. Res., 1916-17, iv, 818.

GREIG, E. D. W.: Antiberi-beri vitamine in ground nut meal biscuits. Indian J. Med. Res., 1918, vi, 143.

GRIJNS, G.: Polyneuritis in fowls. Geneesk Tidsch. v. Ned. Ind., 1901, xli, 3.

GUERRERO, L. E., AND CONCEPCION: Xerophthalmia in fowls on polished rice and its clinical importance. Ph. J. Sci., 1910, xvii, 99.

DE HAAN: On the etiology of beri-beri. Ph. J. Sci., 1910, v, B, 65.

HALLIBURTON, W. D., AND DRUMMOND, J. C.: The nutrition value of margarines and butter substitutes with reference to their content of the fat soluble accessory growth substance. J. Physiol., 1917, li, 235.

HALLIBURTON, W. D.: Les Vitamines Scientia, 1920, xxvii, 55.

HAMMETT: The effect of the maternal ingestion of desiccated placenta upon the rate of growth of breast fed infants. J. Biol. Chem., 1918, xxxvi, 569.

HAUSSLER, E. P.: The vitamine question. Schweiz. Apoth. Ztg., lviii, 621, 634, 655.

HARDEN, A., AND ZILVA, S. S.: A note on the susceptibility of the antiscorbutic principle to alkalinity. Lancet, London, 1918, ii, 320.

HARDEN, A., AND ZILVA, S. S.: Accessory factors in the nutrition of the rat. Biochem. J., 1918, xii, 408.

HARDEN AND ZILVA, S. S.: The differential behavior of the antineuritic and antiscorbutic factors towards adsorbents. Biochem. J., 1918, xii, 93.

HARDEN AND ZILVA, S. S.: The antiscorbutic factor in lemon juice. Biochem. J., 1918, xii, 259.

HARDEN AND ZILVA, S. S.: Note on the etiology of scurvy in guinea pigs. Biochem. J., 1918, xii, 270, 27.

HARDEN AND ZILVA, S. S.: The alleged antineuritic properties of the alpha- hydroxy-pyridine and adenine. Biochem. J., 1917, xi, 172.

HARDEN AND ZILVA, S. S.: Dietetic experiments with frogs. Biochem. J., 1920, xiv, 263.

HARDEN, A.: Vitamins and the food supply. Journ. Soc. of Chem. Ind., 1921, xl, 74.

HARDEN, A., AND ROBISON, R.: The antiscorbutic properties of concentrated fruit juices. Biochem. J., 1920, xiv, 171.

HARDEN, A., AND ZILVA S. S.: The antiscorbutic requirements of the monkey. Biochem. J., 1920, xiv, 131.

HARRIS, W. A,: The experimental production of pellagra in the monkey. J. Am. Med. Assn., 1914, Ixiii, 1093.

HART, C., AND LESSING: Der Skorbut der kleinen Kinder. Stuttgart, 1913.

HART AND MCCOLLUM: The influence on growth of rations restricted to corn or wheat grain. J. Biol. Chem., 1914, xix, 373.

HART, MILLER AND MCCOLLUM: Further studies on the nutritive deficiencies of wheat and grain mixtures and the pathological conditions produced in swine by their use. J. Biol. Chem., 1916, xxv, 239.

HART, HALPIN AND MCCOLLUM: The behavior of chickens restricted to the cereal grains. J. Biol. Chem., 1917, xxix, 57.

HART, HALPIN AND STEENBOCK: The behavior of chickens restricted to the wheat or maize kernel. J. Biol. Chem., 1917, xxxi, 415.

HART AND STEENBOCK: Maintenance and reproduction value of some protein mixtures. J. Biol. Chem., 1919, xxxviii, 267.

HART, STEENBOCK AND SMITH: Studies of experimental scurvy. The effect of heat on the antiscorbutic properties of some milk products. J. Biol. Chem., 1919, xxxviii, 305.

HART AND STEENBOCK: Maintenance and reproduction with grains and grain products as sole dietary. J. Biol. Chem., 1919, xxxix, 209.

HART, STEENBOCK AND ELLIS: Influence of diet on the antiscorbutic potency of milk. J. Biol. Chem., 1920, xlii, 383.

HAWK, P. B., SMITH AND BERGHEIM. The vitamine content of honey and the honey comb. Am. J. Physiol., 1921, lv, 339.

HEHIR: Beri-beri. Proc. Asiatic Soc. Bengal, 1919, xv, ccxii.

HEISER: Practical experience with beri-beri in the Philippine Islands. Ph. J. of Sci., 1911, vi, B, 229.

HERZOG: Beri-beri in the Japanese Army during the late war. Ph. J. of Sci., 1906, i, 169.

HERZOG: Studies in beri-beri. Ph. J. of Sci., 1906, i, 709.

HESS, A. F.: Scurvy past and present. Book. J. B. Lippincott, 1920.

HESS, A. F., AND FISH: Infantile Scurvy. The blood, the blood vessels and the diet. Am. J. Dis. Chil., 1914, viii, 385.

HESS, A. F.: Infantile Scurvy. Its influence on growth. Am. J. Dis. Children, 1916, xii, 152.

HESS, A. F.: Infantile Scurvy. The therapeutic value of yeast and wheat embryo. Am. J. Dis. Chil., 1917, xiii, 98.

HESS, A. F.: Infantile Scurvy. A study of its pathogenesis. Am. J. Dis. Chil., 1917, xiv, 189.

HESS, A. F.: Subacute and latent scurvy. J. Am. Med. Assn., 1917, lxviii, 235.

HESS, A. F., AND UNGER, L. J.: Experiments on antiscorbutics. Proc. Soc. Exp. Biol. and Med., 1918, xv, 141.

HESS, A. F., AND UNGER, L. J.: Scorbutic beading of the ribs. Am. J. Dis. Children, 1920, xix, 331.

HESS, A. F., AND UNGER, L. J.: The Scurvy of guinea pigs. I. The experimental dietary. J. Biol. Chem., 1918, xxxv, 479.

HESS, A. F., AND UNGER, L. J.: The Scurvy of guinea pigs. II. The effect of addition of fruits and vegetables to the dietary. J. Biol. Chem., 1918, xxxv, 487.

HESS, A. F., AND UNGER, L. J.: Factors affecting the antiscorbutic value of foods. Am. J. Dis. Chil., 1919, xvii, 221.

HESS, A. F., AND UNGER, L. J.: The Scurvy of Guinea pigs. III. The effect of age, heat, and reaction upon antiscorbutic foods, J. Biol. Chem., 1919, xxxviii, 293.

HESS, A. F., AND UNGER, L. J.: Proc. Soc. Exp. Biol. and Med., 1919, xvi, 52.

HESS, A. F.: The rôle of fat-soluble vitamine and its relation to rickets. J. Biol. Chem., 1920, xli, xxxii, Proc.

HESS, A. F., AND UNGER, L. J.: The clinical rôle of the fat-soluble vita- mine; its relation to rickets. J. Am. Med. Assn., 1920, lxxlv, 217.

HESS, A. F., AND UNGER, L. J.: The rôle of the fat-soluble vitamine in the dietary of infants. Proc. Soc. Exp., Biol. and Med., 1919, xvii, 49.

HESS, A. F., UNGER, L. J., AND SUPPLEE, G. C.: Relation of fodder to the antiscorbutic potency and salt content of milk. J. Biol. Chem., 1920, xlv, 229.

HESS, A. F.: Newer aspects of some nutritional disorders. J. Am. Med. Assn., 1920, lxxvi, 693.

HESS, A. F., AND UNGER, L. J.: Prophylactic therapy for rickets in a negro community. J. Am. Med. Assn., 1917, lxix, 1583.

HESS, A. F.: Rôle of antiscorbutics in our dietary. J. Am. Med. Assn., 1918, lxxi, 941.

HIGHET: Beri-beri in Siam. Ph. J. of Sci., 1910, v, B, 73.

HOFMEISTER, F.: Zur kenntniss der alkaloidischen Bestandtheile der Reis- kleie. Bioch. Ztschr., 1920, ciii, 218.

HOGAN: The nutritive properties of corn. J. Biol. Chem., 1916, xxvii.

HOGAN: The nutritive properties of kaffir corn. J. Biol. Chem., 1918, xxxiii, 151.

HOULBERT: Vitamines and growth. Paris Medicale, 1919, xx, No. 5.

HOWE, P. R.: Scorbutic diets and teeth. Dental Cosmos, 1920, lxii, 1701.

HOWE, P. R.: Dental caries. Dental Cosmos, 1920, lxii, 921.

HOWE, P. R.: Food accessory factors in relation to teeth. J. Home Econ., xii, 482, (1920).

HOLST, A.: J. Hyg., 1907, vii, 619.

HOLST AND FROHLICH: Experimental studies relating to ship beri-beri and scurvy. J. Hyg. Cambridge, 1907, vii, 634.

HOLST AND FROHLICH: Experimental Scurvy. Ztschr. f. Hyg. u. Infektionkrankh., Leipzig, 1912, lxxii, 1, and lxxv, 334.

HOOBLER, B. R.: Problems connected with the collection and production of human milk. J. Am. Med. Assn., 1917, lxix, 421, (1917).

HOOBLER, B. K.: The effect on human milk production of diets containing various forms and quantities of protein. Am. J. Dis. Chil., 1917, xiv, 105.

HOPKINS, F. G.: Feeding experiments illustrating the importance of accessory factors in normal dietaries. J. Physiol., 1912, xliv, 425.

HOPKINS, F. G., AND NEVILLE: A Note concerning the influence of diets on growth. Biochem. J., 1913, vii, 97.

HOPKINS, F. G.: A Note on the vitamine content of milk. Biochem. J. 1920, xiv, 721.

HOPKINS, F. G.: The effect of heat and aeration upon the fat-soluble vitamine. Biochem. J., 1920, xiv, 725.

HOPKINS, F. G.: Dietetic deficiencies (Discussion). Proc. Roy. Med. Soc., 1920, xiii (Section of Therapeutics and Pharmacology).

HOPKINS, F. G., AND CHICK, H.: Accessory factors in food. Lancet, London, ii, 28,1919.

HOWLAND, J., AND PARK, S. A. i Some observations on rickets. Arch. Pediats., 1920, xxxvii, 411.

HUTCHISON, H. S.: Is fat starvation a causal factor in production of rickets. Glasgow Med. J., Jan., 1920, xi, N. S.

IZUME, S.: Cholic acid poisoning. J. Tokyo Chem. Soc., 1920, xli, 225.

JACKSON, F. G., AND HARLEY, V.: An experimental inquiry into scurvy. Proc. Roy. Soc., 1900, lxvii, 250.

JACKSON, F. G., AND HARLEY, V.: An experimental inquiry into scurvy. Lancet, London, 1900, i, 1184.

JACKSON, L., AND MOORE, J. J.: Studies on experimental scurvy in guinea pigs. J. Infect, Dis., 1916, xix, 478.

JACKSON, L., AND MOODY, A. M.: Bacteriologic studies on experimental scurvy in guinea pigs. J. Infect. Dis., 1916, xix, 511.

JAFFA, M. E.: Further investigations among fruitarians. U. S, Dept. Agric. Off. Exper. St. Bull. 132, 1903.

JANSEN, B. C. P.: Fat soluble vitamine in coconut oil. Geneesk. Tidschr. von Med. Indie, lviii, 173.

JANSEN, B. C. P., AND MANGKOEWINOTO, R. M. M.: On the respiratory quotient of birds fed on polished rice. Med. geneesk. labte, Weltoreden Java, 1920 Ser. A., Nos. 1, 2, 3, and 50.

JANSEN, B. C. P.: On the vitamine amount of extract of rice bran and the methods of estimating it. Med. geneesk. labte, Weltoreden Java, 1920 Ser. A., Nos. 22-49.

JOBBING, J. W., AND PETERSEN, W.: A preliminary report upon the epidemiology of pellagra in Nashville, Tennessee. J. Infect. Dis., 1916, xviii, 501; 1917, xxi, 109.

KAKR, W. G.: Some effects of water-soluble B on nutrition. J. Biol. Chem., 1920, xliv, 255.

KARR, W. G.: Metabolism studies with diets deficient in water-soluble B. J. Biol. Chem., 1920, xliv, 277.

KARR, W. G.: Water-soluble vitamine in the nutrition of dogs. Proc. Soc. Exp. Biol. and Med., 1920, xvii, 84.

KILBOURNE: Food salts in relation to beri-beri. Ph. J. of Sci., 1910, v, B, 127.

KLIGLER: Growth accessory substances for pathogenic bacteria in animal tissues. J. Exper. Med., 1919, xxx, 31.

KOHMAN, E. A.: The experimental production of edema as related to protein deficiency. Am. J. of Physiol., 1920, li, 185 and 378.

LANE-CLAYPON, J. E.: Milk and its hygienic relations. London, N. Y., Bombay and Calcutta, 1916.

LAQUEUR: 11th Congress Physiol., Gruningen, 1913.

LARSON, J. H.: Butter fat and growth of children. Arch, of Pediatrics, 1920, xxxvii, 610.

LAVINDER, C. H., AND FRANCIS, E.: Attempts to transmit pellagra to monkeys. J. Am. Med. Assn., 1914, lxiii, 1093.

LEWIS, R. C.: The chemical composition of the blood of pellagrins. U. S. Hyg. Lab. Bull. 116, 1920.

LEWIS, H. B.: The antiscorbutic value of the banana. J. Biol. Chem., 1919, xl, 91.

LEWIS, H. B., AND KARR, W. G.: Changes in the urea content of blood and tissues of guinea pigs maintained on an exclusive oat diet. J. Biol. Chem., 1916-17, xxviii, 17.

LIND, J.: A treatise on scurvy. London, 2nd ed., 1757.

LIND, J.: An essay on diseases incidental to Europeans in hot climates. 2nd ed., London, 1771.

LINOSSIER, G.: Vitamines and fungi. Compt. rend. soc. biol., lxxxii, 381, (1919).

LINTON, R. G.: Vitamines, Science and Ind., Australia, 1920, ii, 438.

LLOYD: On vitamines, amino acids and other factors involved in the growth of meningococcus. J. Path. and Bacteriol., 1916-17, xxi, 113.

LUMIERE, A.: The alleged reserves of vitamines. Paris Medicale, 1920, x, 474.

LUMIERE, A.: Avitaminosis and inanition. Bull. de l'academie de Med. Paris, 1920, lxxxiv, 274.

LUMIERE, A.: Are vitamines necessary to the development of plants. Compt. rend., clxxi, (1920), 271.

LUMIERE, A.: Starvation of pigeons fed on hulled rice. Bull. de l'academie de Med., Paris., 1920, lxxxiii, 310.

MARRIOTT AND MCKIM: The artificial feeding of athreptic infants. J. Am. Med. Assn., 1919, lxxiii, 1173.

MARTINEZ, F. F.: Le premier cas de beri-beri dans la peninsule iberique. Arch. mde. belges 1920, lxxiii, 299.

MASTERS, H., AND GARBUTT, P.: An investigation of the methods employed in cooking vegetables. I. Dried legumes. Biochem. J., 1918, xii, 231. II. Green vegetables. Biochem. J., 1920, xiv, 75.

MATTILL, H. A., AND CONKLIN, R. E.: The nutritive properties of milk with special reference to reproduction. J. Biol. Chem., 1920, xliv, 137.

MEEK, L.: Die hauterscheinungen der pellagra. Innsbruck, 1909.

MENDELL AND FINE: The utilization of the proteins of wheat, barley, corn, legumes and extractive free meal powder. J. Biol. Chem., 1911-12, x, 303, 339, 345, 433, and xi, 5.

MELLANBY, E., AND OTHERS: Vitamines and infant feeding. Proc. Roy. Soc. Med., 1920, xiii, 57, Sec. Dis. of Children.

MELLANBY, E., AND OTHERS: Vitamines and infant feeding. Lancet, London, 1920, i, 856.

MENDOZA-GUAZON, M. P.: Study of the anatomico-pathologic lesions in one thousand Filipino children under five years. Ph. J. Sci., 1917, xii, B, 51.

MILLER, E. W.: The effect of cooking on the water-soluble vitamine in carrots and navy beans. J. Biol. Chem., 1920, xliv, 159.

MITCHELL, H. H., AND NELSON: The preparation of protein free milk. J. Biol. Chem., 1915, xxiii, 459.

MITCHELL, H. H.: On the identity of water-soluble growth promoting vitamine and antineuritic vitamine. J. Biol. Chem., 1919, xl, 399.

MOCKENRIDGE, F. A.: Some effects of growth promoting substances, auximones, on the soil organisms concerned in the nitrogen cycle. Proc. Roy. Soc. London, series B, 1917, lxxxix, 508.

MOCKENRIDGE, F. A.: The occurrence and nature of the plant growth promoting substances in various organic manurial composts. Biochem. J., 1920, xiv, 432.

MORSE, J. L.: A resume of the literature of infantile scurvy during the past two years. Boston Med. Surg. Journal, 1920, clxxxii, 428.

MOULTON: The availability of the energy of food for growth. J. Biol. Chem., 1917, xxxi, 389.

MOURIQUAND, G., AND MICHEL, P.: Le scorbut experimentale du cobaye, est-il du constipation. Compt. rend. soc. biol., 1920, lxxxiii, 62.

MUCKENFUSS, A. M.: The presence of food accessories in urine, bile and saliva. J. Am. Chem. Soc., 1918, xl, 1606.

MURLIN, J. R.: The amino acid factors and hippuric acid in the urine of pellagrins. U. S. Hyg. Lab. Bull. No. 116, 1920.

MYERS, C. N., AND VOEGTLIN, C.: The chemical isolation of the vitamines. J. Biol. Chem., 1920, xlii, 199.

MCCARRISON, R.: Deficiency disease. British Med. Journ., 1920, i, 822.

MCCARRISON, R.: The effects of deficiency dietaries on monkeys. British Med. Journ., 1920, i, 249.

MCCARRISON, R.: The genesis of edema in beri-beri. Proc. Roy. Soc., 1920, B, 91 & 103.

MCCARRISON, R.: The pathogenesis of deficiency disease. Indian Journ. Med. Research, 1919, vi, 275, 550; vii, 167, 188, 269, 279, 308, 342, 633.

MCCLENDON, J. F., COLE, W. C. C., ENGSTRAND, 0., AND MIDDLEKAUFF, J. E.: The effect of Malt and malt extracts on scurvy and on the alkaline reserve of the blood. J. Biol. Chem., 1919, xl, 243.

MCCLENDON, J. F., AND SHARP, P. F.: Determination of the pH concentration of foods during storage and preparation in relation to the preservation of antiscorbutic properties. J. Biol. Chem., 1920, xli, p. iv Proc.

MCCLENDON, J. F.: Nutrition and public health with special reference to vitamines. Amer. J. Med. Sciences, 1920, clix, 477.

MCCOLLUM, E. V., AND DAVIS, M.: The necessity of certain lipins in the diet during growth. J. Biol. Chem., 1913, xv, 167.

MCCOLLUM, E. V., AND DAVIS, M.: Proc. Soc. Exp. Biol. and Med., 1913-14, xi, 101.

MCCOLLUM, E. V., AND DAVIS, M.: Observations on the isolation of the substance in butter fat that exerts a stimulatory action upon growth. J. Biol. Chem., 1914, xix, 245.

MCCOLLUM, E. V.: The value of the proteins of the cereal grains and milk for growth in the pig and the influence of the plane of protein intake on growth. J. Biol. Chem., 1914, xix, 323.

MCCOLLUM, E. V., AND DAVIS, M.: The influence of the plane of protein intake in growth. J. Biol. Chem., 1915, xx, 415.

MCCOLLUM, E. V., AND DAVIS, M.: Nutrition with purified food substances. J. Biol. Chem., 1915, xx, 641.

MCCOLLUM, E. V., AND DAVIS, M.: The influence of certain vegetable fats on growth. J. Biol. Chem., 1915, xxi, 179.

MCCOLLUM, E. V., AND DAVIS, M.: The influence of the composition and amount of mineral content of the ration on growth and reproduction. J. Biol. Chem., 1915, xxi, 615.

MCCOLLUM, E. V., AND DAVIS, M.: The nature of the dietary deficiencies of rice. J. Biol. Chem., 1915, xxiii, 181.

MCCOLLUM, E. V., AND DAVIS, M.: The essential factors in the diet during growth. J. Biol. Chem., 1915, xxiii, 231.

MCCOLLUM, E. V., AND DAVIS, M.: The cause of the loss of the nutritive efficiency of heated milk. J. Biol. Chem., 1915, xxiii, 247.

MCCOLLUM, E. V., SIMMONDS, N., AND PITZ: Proc. Soc. Exp. Biol. and Med., 1916, xiii, 129.

MCCOLLUM, E. V., AND KENNEDY: Dietary factors operating in the production of polyneuritis. J. Biol. Chem., 1916, xxiv, 491.

MCCOLLUM, SIMMONDS AND PITZ: The relation of the unidentified dietary factors fat-soluble A and water-soluble B of the diet to the growth promoting properties of milk. J. Biol. Chem., 1916, xxvii, 33.

MCCOLLUM, SIMMONDS AND PITZ: The nature of the dietary deficiencies of the wheat embryo. J. Biol. Chem., 1916, xxv, 105.

MCCOLLUM, SIMMONDS AND PITZ: The vegetarian diet in the light of our present knowledge and the distribution in plants of fat-soluble A. Am. J. Physiol., 1916; xli, 333, 361 and 374.

MCCOLLUM, SIMMONDS AND PITZ: The dietary deficiencies of the maize kernel. J. Biol. Chem., 1916-17, xxviii, 153.

MCCOLLUM, SIMMONDS AND PITZ: The effect of feeding the proteins of the wheat kernel at different planes of intake. J. Biol. Chem., 1916-17, xxviii, 211.

MCCOLLUM, SIMMONDS AND PITZ: Is lysine the limiting ammo acid in proteins of wheat, maize and oats? J. Biol. Chem., 1916-17, xxviii, 483.

MCCOLLUM, E. V.: The Harvey Lectures, 1916-17, xii, 151.

MCCOLLUM, SIMMONDS AND PITZ: The nature of the dietary deficiencies of the oat kernel. J. Biol. Chem., 1917, xxix, 341.

MCCOLLUM, SIMMONDS AND PITZ: The dietary deficiencies of the white bean. J. Biol. Chem., 1917, xxix, 521.

MCCOLLUM, SIMMONDS AND PITZ: The supplementary dietary relations between leaf and seed as contrasted with combinations of seed with seed. J. Biol. Chem., 1917, xxx, 13.

MCCOLLUM AND PITZ: The vitamine hypothesis and deficiency diseases. J. Biol. Chem., 1917, xxxi, 229.

MCCOLLUM, E. V., AND SIMMONDS: A biological analysis of pellagra producing diets. I. The dietary properties of mixtures of maize kernel and bran. J. Biol. Chem., 1917, xxxii, 29.

MCCOLLUM, E. V., AND SIMMONDS: A biological analysis of pellagra producing diets. II. The minimum requirements of the two unidentified dietary factors for maintenance as contrasted with growth. J. Biol. Chem., 1917, xxxii, 347.

MCCOLLUM, E. V., AND SIMMONDS: A biological analysis of pellagra producing diets. III. The values of some seed proteins for maintenance. J. Biol. Chem., 1917, xxxii, 347.

MCCOLLUM, E. V.: The supplementary dietary relations among our natural food stuffs. J. Am. Med. Assn., 1917, lxviii, 1379.

MCCOLLUM AND SIMMONDS: A study of the dietary essential, water-soluble B in relation to its solubility and stability toward reagents. J. Biol. Chem., 1918, xxxiii, 55.

MCCOLLUM AND SIMMONS: Pellagra IV. The causes of failures of mixtures of seeds to promote growth in young animals. J. Biol. Chem., 1918, xxxiii, 303.

MCCOLLUM AND SIMMONS: Pellaga V. The nature of the dietary deficiencies of a diet derived from peas, wheat flour and cotton seed oil. J. Biol. Chem., 1918, xxxiii, 411.

MCCOLLUM, SIMMONDS AND PARSONS: The dietary properties of the potato. J. Biol. Chem., 1918, xxxvi, 197.

MCCOLLUM, E. V., AND SIMMONDS: The nursing mother as a factor of safety in the nutrition of the young. Am. J. Physiol., 1918, xlvi, 275.

MCCOLLUM, E. V.: The Newer Knowledge of Nutrition, a book. Macmillan, 1919.

MCCOLLUM, SIMMONDS AND PARSONS: The dietary properties of the pea. J. Biol. Chem., 1919, xxxvii, 287

MCCOLLUM AND PARSONS: The etiology of rickets. J. Biol. Chem., 1920, xli, p. xxxi of the proceedings.

MCCOLLUM AND PARSONS: The antiscorbutic requirements of the Prairie dog. J. Biol. Chem., 1920, xliv, 609.

MCCOLLUM, SIMMONDS, SHIPLEY, AND PARK.: Studies on the experimental production of rickets. I. The production of rickets and similar diseases in the rat by different diets. J. Biol. Chem., 1921, xlv, 333; and II. The effect of cod-liver oil administered to rats with experimental rickets. J. Biol. Chem., 1921, xlv, 343

MACDOUGAL, D. J.: The effects of yeast vitamine water-soluble B on plant cell masses and on biocolloids. Proc. Soc. Exp. Biol. and Med., 1920, xviii, 39.

MACDONALD AND MCCOLLUM: J. Biol. Chem., 1921, xlv, 307.

MACKAY, H. M. M.: Observations on rickets in an out-patient department. Brit. Med. Journal, 1920, II, 929.

MACKENZIE-WALLIS, R. L.: Food value of the ground nut (Arachis). Ind. J. Med. Res., 1918, vi, 45.

NELSON, V. E., AND LAMB, A. R.: Vitamine deficiency. I. Xerophthalmia in rickets. Am. J. Physiol., 1920, li, 530.

NELSON, V. E., FULMER, E. L., AND CESSNA, R.: The nutritional requirements of yeast. III. The synthesis of the water-soluble B by the yeast. J. Biol. Chem., 1921, xlvi, 77.

NESBITT, CHAS. T.: Sanitation in the control of pellagra. J. Am. Med. Assn., 1916, lxvi, 647.

NORTHROP: The rôle of yeast in the nutrition of an insect (Drosophila). J, Biol. Chem., 1917, xxx, 181.

NOVARO, P.: Gaz. degli, Ospedali, Milan, 1920, xli, 424.

NOVARO, P.: Richerche calorimetriche comparative sul diguino e sull avitaminosi. Pathologica, 1920, xii, 133.

OSBORNE, T. B., AND MENDEL, L. B.: Feeding experiments with isolated food substances. Pub. Carnegie Inst. Bull., 1911, Pts. I and II, No. 156.

OSBORNE, T. B., AND MENDEL, L. B.: Feeding experiments with fat-free food mixtures. J. Biol. Chem., 1912, xii, 81.

OSBORNE, T. B., AND MENDEL, L. B.: The rôle of gliadin in nutrition. J. Biol. Chem., 1912, xii, 473.

OSBORNE, T. B., AND MENDEL, L. B.: Maintenance experiments with isolated proteins. J. Biol. Chem., 1913, xiii, 233.

OSBORNE, T. B., AND MENDEL, L. B.: The relation of growth to the chemical constituents of the diet. J. Biol. Chem., 1913, xv, 311.

OSBORNE, T. B., AND MENDEL, L. B.: The influence of butter fat on growth. J. Biol. Chem., 1913-14, xvi, 423.

OSBORNE, T. B., AND MENDEL, L. B.: Amino acids in nutrition. J. Biol. Chem., 1914, xvii, 325.

OSBORNE, T. B., AND MENDEL, L. B.: The influence of cod-liver oil and some other fats on growth. J. Biol. Chem., 1914, xvii, 401.

OSBORNE, T. B., AND MENDEL, L. B.: Nutritive properties of the maize kernel. J. Biol. Chem., 1914, xviii, 1.

OSBORNE, T. B., AND MENDEL, L. B.: The repression of growth and the capacity to grow. J. Biol. Chem., 1914, xviii, 95.

OSBORNE, T. B., AND MENDEL, L. B.: Further observations on the influence of natural fats on growth. J. Biol. Chem., 1915, xx, 379.

OSBORNE, T. B., AND MENDEL, L. B.: The comparative nutritive value of certain proteins and the problem of protein minimum. J. Biol. Chem., 1915, xx, 351.

OSBORNE, T. B., AND MENDEL, L. B.: Protein minima for maintenance. J. Biol. Chem., 1915, xxii, 241.

OSBORNE, T. B., AND MENDEL, L. B.: The resumption of growth after long- continued failure to grow. J. Biol. Chem., 1915, xxiii, 439.

OSBORNE, T. B., AND MENDEL, L. B.: The stability of the growth-promoting substance in butter fat. J. Biol. Chem., 1916, xxiv, 37.

OSBORNE, T. B., AND MENDEL, L. B.: The amino acid minimum for maintenance and growth as exemplified by further experiments with lysine and tryptophane. J. Biol. Chem., 1916, xxv, 1.

OSBORNE, T. B., AND MENDEL, L. B.: A quantitative comparison of casein, lactalbumin and edestin for growth and maintenance. J. Biol. Chem., 1916, xxvi, 1.

OSBORNE, T. B., AND MENDEL, L. B.: The effect of the amino acid content of the diet upon the growth of chickens. J. Biol. Chem., 1916, xxvi, 293.

OSBORNE, T. B., AND MENDEL, L. B.: The relative value of certain proteins and protein concentrates as supplements to corn gluten. J. Biol. Chem., 1917, xxix, 69.

OSBORNE, T. B., AND MENDEL, L. B.: The use of cotton-seed as food. J. Biol. Chem., 1917, xxix, 289.

OSBORNE, T. B., AND MENDEL, L. B.: The rôle of vitamines in the diet. J. Biol. Chem., 1917, xxxi, 149.

OSBORNE, T. B., AND MENDEL, L. B.: Nutritive factors in animal tissues. J. Biol. Chem., 1917, xxxii, 309.

OSBORNE, T. B., AND MENDEL, L. B.: The use of the soy-bean as food. J. Biol. Chem., 1917, xxxii, 369.

OSBORNE, T. B., AND MENDEL, L. B.: Some new constituents of milk. J. Biol. Chem., 1918, xxxiii, 243.

OSBORNE, T. B., AND MENDEL, L. B.: The growth of chickens in confinement. J. Biol. Chem., 1918, xxxiii, 433.

OSBORNE, T. B., AND MENDEL, L. B.: Nutritive factors in animal tissues. II. J. Biol. Chem., 1918, xxxiv, 17.

OSBORNE AND MENDEL: The inorganic elements in nutrition. J. Biol. Chem., 1918, xxxiv, 131.

OSBORNE AND MENDEL: Nutritive factors in plant tissues. I. The protein factors in the seeds of cereals. J. Biol. Chem., 1918, xxxiv, 521.

OSBORNE AND MENDEL: Milk as a source of water-soluble vitamin. J. Biol. Chem., 1918, xxxiv, 537.

OSBORNE AND MENDEL: The choice between an adequate and inadequate diet as made by rats. J. Biol. Chem., 1918, xxxv, 19.

OSBORNE AND MENDEL: The vitamines in green foods. J. Biol. Chem., 1919, xxxvii, 187.

OSBORNE AND MENDEL: A method of expressing numerically the growth- promoting value of proteins. J. Biol. Chem., 1919, xxxvii, 223.

OSBORNE AND MENDEL: The nutritive value of the wheat kernel and its milling products. J. Biol. Chem., 1919, xxxvii, 557.

OSBORNE AND MENDEL: The nutritive value of yeast protein. J. Biol. Chem., 1919, xxxviii, 223.

OSBORNE AND MENDEL: Nutritive factors in plant tissues. II. The distribution of water-soluble vitamin. J. Biol. Chem., 1919, xxxix, 29.

OSBORNE AND MENDEL: Nutritive value of the proteins of the barley, oat, rye and wheat kernel. J. Biol. Chem., 1920, xli, 275.

OSBORNE AND MENDEL: Nutritive factors in plant tissues. III. Further observations on the distribution of water-soluble vitamin. J. Biol. Chem., 1920, xli, 451.

OSBORNE AND MENDEL: Fat soluble vitamine of green foods. J. Biol. Chem., 1920, xli, p. vii.

OSBORNE AND MENDEL: Milk as a source of water soluble vitamin II. J. Biol. Chem., 1920, xli, 515.

OSBORNE AND MENDEL: Nutritive factors in plant tissues. IV. Fat-soluble vitamine. J. Biol. Chem., 1920, xli, 549.

OSBORNE AND MENDEL: The occurrence of water-soluble vitamin in some common fruits. J. Biol. Chem., 1920, xlii, 465.

OSBORNE AND MENDEL: Skimmed milk as a supplement to corn in feeding. J. Biol. Chem., 1920, xliv, 1.

OSBORNE AND MENDEL: A critique of experiments with diets free from fat- soluble vitamin. J. Biol. Chem., 1921, xlv, 277.

OSBORNE AND MENDEL: Growth on diets poor in true fats, J. Biol. Chem., 1920, xlv, 145.

OSBORNE AND MENDEL: Do fruits contain water-soluble B. Proc. Soc. Exper. Biol. and Med., 1919, xvii, 46.

OSBORNE AND MENDEL: The growth of rats upon diets of isolated food substances. Biochemical Journal, 1916, x, 534.

OSBORNE, T. B., AND MENDEL, L. B.: Ophthalmia and diet. J. Am. Med. Assn., 1921, lxxvi, 905.

OSBORNE, T. B., and WAKEMAN, A.: Does butter fat contain N and P? J. Biol. Chem., 1915, xxi, 91.

OSBORNE, T. B., AND WAKEMAN, A.: The proteins of cow's milk, J. Biol. Chem., 1918, xxxiii, 7.

OSBORNE, T. B., AND WAKEMAN, A.: Some new constituents of milk. J. Biol. Chem., 1918, xxxiii, 243.

OSBORNE, T. B., AND WAKEMAN, A.: Extraction and concentration of the water-soluble vitamine from brewer's yeast. J. Biol. Chem., 1919, xl, 383.

OSBORNE, T. B., AND FERRY, E.: Preparation of protein free from water- soluble vitamin. J. Biol. Chem., 1919, xxxix, 35.

OWEN, R. C.: The truth about vitamins. Am. J. Pharmacy, 1920, xcii, 467.

PACINI AND RUSSELL: The presence of a growth producing substance in cultures of typhoid bacilli. J. Biol. Chem., 1918, xxxiv, 43.

PADUA, R. G.: Cystolithiasis among Filipinos and dietetic deficiency. Ph. J. Sciences, 1919, xiv, 481.

PALMER AND ECKLES: Chemical and physiological relation of pigment of milk fat to carotin and xanthophyll of green plants. J. Biol. Chem., 1914, xvii, 191.

PALMER AND ECKLES: The pigments of the body fat, corpus luteum and the skin secretions of the cow. J. Biol. Chem., 1914, xvii, 211.

PALMER AND ECKLES: The yellow lipochrome of the blood serum. J. Biol. Chem., 1914., xvii, 223.

PALMER AND ECKLES: The fate of carotin and xanthophyll during digestion. J. Biol. Chem., 1914, xvii, 237.

PALMER AND ECKLES: The pigments of human milk fat. J. Biol. Chem., 1914, xvii, 245.

PALMER AND COOLEDGE: Lactochrome. The yellow pigment of milk whey; its probable identity with urochrome, the specific yellow pigment of normal urine. J. Biol. Chem., 1914, xiv, 251.

PALMER: Xanthophyll, the principal natural yellow pigment of the egg yolk, body fat and blood serum of the hen. J. Biol. Chem., 1915, xviii, 23.

PALMER: The physiological relation of the pigment to the xanthophyll of plants. J. Biol. Chem., 1915, xvii, 261.

PALMER: The physiological relation of plant carotinoids to the carotinoids of the cow, horse, sheep, goat, pig, hen. J. Biol. Chem., 1916, xxvii, 23.

PALMER AND KEMPSTER: The relation of plant carotinoids to growth, fecundity and reproduction of fowls. J. Biol. Chem., 1916, xxxix, 299.

PALMER AND KEMPSTER: The physiological relation between fecundity and the natural yellow pigmentation of certain breeds of fowls. J. Biol. Chem., 1919, xxxix, 313.

PALMER AND KEMPSTER: The influence of certain feeds and certain pigments on the color of egg yolk and body fat of fowls. J. Biol. Chem., 1919, xxxix, 331.

PALMER AND KEMPSTER: Carotinoids and, fat-soluble vitamin. Science, 1919, l, 1.

PORTER, P.: Regeneration du testicule chez le pigeon carence. Compt. rend., clix, 1920, 1339.

PORTER, P.: Creation de vitamines dans l'intestin des lapins recevant une nourriture sterilisée a haute temperature. Compt. rend. 1920, clxx, 478.

PRITCHARD, E.: The causation and treatment of rickets. Brit. Med. J., 1919, 627.

PAGLIESE, A.: Sull problema delle vitamine. Rendiconti R. Inst. Lomb. Sc. e Lett., 1919, lii, 723.

RAMSDEN, W.: Vitamines. Dental Rec., 1920, xl, 281.

RANWEK, F.: New theories of the value of foods in relation to the repression of fraud. J. pharm. belg., 1920, ii, 537.

RICHARD, W. F., AND MACKINNON, W. D.: Scurvy among adults in Glasgow. Glasgow Med. J., 1920, xii, 336.

RICHARDSON AND GREEN: Nutrition investigations upon cotton-seed meal. J. Biol. Chem., 1916, xxv, 307.

RICHARDSON AND GREEN: Nutrition investigations on cotton-seed meal. II. J. Biol. Chem., 1917, xxvi, 243.

RICHARDSON AND GREEN: Nutrition investigations upon cotton-seed meal, cottonseed flour and the nature of its growth-promoting substance. J. Biol. Chem., 1917, xxxi, 379.

ROBB, E. F.: Influence of dry versus fresh green plant tissue on calcium metabolism. Science, 1920, lii, 510.

ROBERTSON, T. BRAILSFORD: Experimental studies on growth. J. Biol. Chem., 1916, xxiv, 24, 347, 363, 385, 397, 409; 1916, xxv, 635, 663 and 1917, xvi, 567.

ROBERTSON, T. B., AND RAY: Studies on Growth. J. Biol. chem., 1919, xxxvii, 377, 393, 427, 443, 455, and 1920, xliv, 439.

ROGER, H.: Present status of our knowledge of ferments. Presse medicale, 1919, xxvii, No. 74.

RÖHMANN, F.: Kunstliche ernährungund Vitamine. Berlin, 1916.

ROSENHEIM, O., AND DRUMMOND, J. C.: Lipochrome pigments and fat-soluble vitamine. Lancet, London, 1920, i, 862.

ROSENHEIM, O.: Accessory factors for plant growth. Biochem. J., 1917, xi, 7.

ROSE, M. S.: The question of child feeding. The Modern Hospital, 1919, xiii, 1.

SCHAEFER, G.: Vitamines and Auximones. Bull. Inst. Pasteur, 1919, xvii, 1 & 41.

SCHAUMANN: Ueber die Darstellung und Werkungsweise der in der Reiskleie enthaltene, gegen polyneuritis wirksauen Substanzen. Arch. f. Schiffs. u. Tropen. Hyg., Cassel, 1912, xvi, 349, & 825.

SCHMORL, G.: Die pathologische Anatomie der rachitischen Knockenerkrankung. Ergebn. u. inn. Med. u. Kinderh., 1914, xii, 403.

SEAMAN, E.: The influence of an alcoholic extract of the thyroid gland upon polyneuritis and the metamorphosis of tadpoles. Am. J. Physiol., 1920, liii, 101.

SEGAWA, M.: Experimental infantile scurvy. Tokyo Igakukai Zasshi, 1918, xii, No. 20.

SEIDELL, A. Vitamines in nutritional diseases. U. S. Public Health Reports No. 325, 1916, xxi, 364.

SEIDELL, A.: The vitamine content of brewer's yeast. J. Biol. Chem., 1917, xxix, 145.

SEIDELL, A.: The chemistry of the vitamines. J. Ind. and Eng. Chem., 1920, xiii, 72.

SEKINE, H.: Nutritive defect of condensed milks. J. Tokyo Chem. Soc., 1920, xli, 439.

SEKINE, H.: Vitamine A in Fish Oils. J. Tokyo Chem. Soc., 1920, xli, 426.

SHEARER: On the presence of an accessory food factor in the nasal secretion and its action on the growth of meningococcus and other pathogenic bacteria. Lancet, London, 1917, i, 59.

SHERMAN, H. C., WHEELER AND YATES: Experiment on the nutritive value of maize protein and on the P and Ca requirements of healthy women. J. Biol. Chem., 1918, xxxiv, 383

SHERMAN, H. C., AND WINTERS: Efficiency of maize protein in adult human nutrition. J. Biol. Chem., 1918, xxxv, 301.

SHERMAN, WINTERS AND PHILLIPS: The efficiency of oat protein in adult human nutrition. J. Biol. Chem., 1919, xxxix, 53.

SHERMAN, MACLEOD, F. L., AND REAMER, M. M.: Preliminary experiments with the fat-soluble vitamine. Proc. Soc. Exp. Biol. and Med., 1920, xviii, 41.

SHIBAYAMA: Some observations concerning beri-beri. Ph. J. Sciences, 1910, v, B, 123.

SHORTENN, J. A., AND ROY, C.: Anti-beriberi vitamine and antiscorbutic property of sun dried vegetables. Proc. Asiatic Soc. Bengal, 1919, xv, and Indian J. Med. Res., Calcutta, 1919, Spec. Congress Nos. 60-78.

SILER, F., GARRISON, P. E., AND MACNEAL, W. J.: A statistical study of the relation of pellagra to use of certain foods and to location of domicile. Arch. Int. Med., 1914, xiv, 293.

SILER, F., GARRISON, P. E., AND MACNEAL, W. J.: An experimental test of the relation of sewage disposal to the spread of pellagra. Arch. Int. Med., 1917, xix, 683.

SILER, F., GARRISON, P. E., AND MACNEAL, W. J.: Relation of pellagra to location of domicile in Spartan Mills and the adjacent district. Arch. Int. Med., 1917, xix, 198.

SIMMONDS AND PARSONS: Supplementary relationships between the proteins of certain seeds. J. Biol. Chem., 1919, xxxvii, 155.

SMITH, A. H.: Meat and Scurvy. Lancet, London, 1918, ii, 813., and J. Roy. Army. Med. Corps, 1919, xxxii, 188.

SOUZA, G. DE P. AND MCCOLLUM, E. V.: A study of the factors which interfere with the use of yeast as a test for the antineuritic substance. J. Biol. Chem., 1920, xliv, 113.

STEENBOCK, H.: J. Biol. Chem., 1917, xxix p. xxvii, Proc.

STEENBOCK, KENT AND GROSS: The dietary qualities of barley, J. Biol. Chem., 1918, xxv, 61.

STEENBOCK, BOUTWELL AND KENT: Fat-soluble vitamine I. J. Biol. Chem., 1918, xxxv, 517.

STEENBOCK AND GROSS: Fat-soluble vitamine II. The fat-soluble vitamine content of roots, together with some observations on their water-soluble content. J. Biol. Chem., 1919, xl, 501.

STEENBOCK, AND BOUTWELL: Fat-soluble vitamine III. The comparative nutritive value of white and yellow maizes. J. Biol. Chem., 1920, xli, 81.

STEENBOCK AND GROSS: Fat-soluble vitamine IV. The fat-soluble vitamine content of green plant tissues together with some observations on their water-soluble vitamine content. J. Biol. Chem., 1920, xli, 149.

STEENBOCK AND BOUTWELL: Fat-soluble vitamine V. Thermostability of the fat-soluble vitamine in plant materials. J. Biol. Chem., 1920, xli, 163.

STEENBOCK, BOUTWELL AND KENT: A correlation on the occurrence of the fat- soluble vitamine. J. Biol. Chem., 1920, xli, p. xii. Proc.

STEENBOCK AND BOUTWELL: Fat-soluble vitamine VI. The extractability of the fat-soluble vitamine from carrots, alfalfa and yellow corn by fat- solvents. J. Biol. Chem., 1920, xlii, 131.

STEENBOCK: White corn vs. yellow corn. Science 1919, L, 1293.

STEFANSSON, V.: Observations on three cases of scurvy. J. Am. Med. Assn. 1918, lxxi, 1715.

STEPHENSON, M.: A Note on the differentiation of the yellow plant pigments from the fat-soluble vitamin. Biochem. J., 1920, xiv, 715.

STEPHENSON, M., AND CLARK, A. B.: A contribution to the study of keratomalacia among rats. Biochem. J., 1920, xiv, 502.

STEPP: Biochemische Ztschr., Berlin, 1909, xxii, 452.

STEPP: Experimentelle untersuchungen ueber die Bedeutungs der Lipoide fur die Ernahrung. Ztschr. f. Biol. Munchen und Leipzig, 1912, lxii, 135, and 1911-13, lix, 366.

STEVENSON, A. G.: Etiology of an outbreak in scurvy in North Russia. J. Roy. Arm. Med. Corps, xxxv, 218.

STANNUS, H. S.: Pellagra in Nyasa Land. Tr. Soc. Trop. Med. and Hyg., 1913, vii, 32.

STRONG AND CROWELL: The etiology of beri-beri. Ph. J. Sc., 1912, vii, B, 271.

SUGIURA AND BENEDICT, S.: The action of radium emanation on the vitamines of yeast. J. Biol. Chem., 1919, xxxix, 421.

SUGIURA: A preliminary report on the preparation of anti-polyneuritic substances from carrots and yeast. J. Biol. Chem., 1918, xxxvi, 191.

SUGIURA AND BENEDICT, S.: The nutritive value of the banana. I. J. Biol. Chem., 1918, xxxvi, 171.

SUGIURA, KANEMATSU AND BENEDICT, S.: The nutritive value of the banana. II. J. Biol. Chem., 1919, xxxix, 449.

SULLIVAN, M. X., AND VOEGTLIN, C.: The distribution in foods of the so- called vitamines and their isolation. J. Biol. Chem., 1916, xxiv, 16.

SULLIVAN, M. X., AND VOEGTLIN, C.: The relation of the lipoids to vitamines. J. Biol. Chem., 1916, xxiv, 17.

SULLIVAN, M. X., AND JONES, K. K.: Chemical composition of the Rankin Farm pellagra producing diet. Bull. 120, U. S. Public Health Reports.

SULLIVAN, M. X.: Biological study of a diet resembling the Rankin Farm pellagra producing diet and feeding experiments with the Rankin diet. Bull. 120. U. S. Public Health Reports.

SUZUKI, SHIMAMURA AND ODAKE: Ueber oryzanin. 1912.

SUZUKI, SHIMAMUEA AND ODAKE: Ueber oryzanin. Biochem. Ztschr. Berlin, 1912, xliii, 89.

SYDENSTRICKER, E.: The prevalence of pellagra: Its possible relation to rise in cost of food. Public Health Report. U. S., 1915, xxx, 3132.

SWOBODA, F. K.: A quantative method for the determination of vitamine in connection with determinations of vitamine in glandular and other tissues. J. Biol. Chem., 1920, xliv, 531.

TELFER, S. V.: The influence of cod-liver oil and butter fat on the retention of Ca and P. J. Physiol., 1921, liv, p. cv, Proc. Physiol. Soc.

THIEBAUT, K.: Complementary factors of growth. Presse Medicale, 1919, xxvii, No. 79.

THOMAS: Biological value of nitrogenous substances in different foods. Arch. Anat. u. Physiol., 1909, 219 and 302.

TORREY, J. C., AND HESS, A. F.: Proc. Soc. Exp. Biol. and Med., 1917-18, xv, 74.

DELP, E. M., AND TOZER: The antiscorbutic value of cabbage. I. Biochem. J., 1918, xii, 416.

TSCHIRCH: Was sind die Vitamine? Schweiz. med. Woch., 1920, l, 12.

UHLMAN, F.: Pharmacological effects of vitamines. Z. Biol., 1917, lxviii, 419, 457.

VEDDER, E. B.: Beri-Beri. London, 1913.

VEDDER: A fourth contribution to the etiology of beri-beri. Ph. J. Sc., 1912, vii, B, 415.

VEDDER AND CLARK: A fifth contribution. Ph. J. Sc., 1912, vii, B, 423.

VEDDER AND WILLIAMS, R. R.: A sixth contribution. Ph. J. Sc., 1913, viii, B, 175.

VEDDER, E. B.: Dietary deficiency as the etiological factor in pellagra. Arch. Int. Med., 1916, xviii, 137.

VERZAR, F., AND BÖGEL, J.: Ueber die Wirkung von akzessoriehen Nahrungs Substanzen. Bioch. Ztschr., 1920, cviii, 156.

VOEGTLIN, C.: The treatment of pellagra. J. Am. Med. Assn., 1914, lxiii, 1094.

VOEGTLIN, C.: Importance of vitamines in relation to nutrition in health and disease. J. Wash. Acad. Sci., 1916, vi, 575.

VOEGTLIN, C., AND LAKE: Am. J. Physiol., 1918-19, xlvii, 558.

VOEGTLIN, C., AND MYERS, C. N.: Distribution of the antineuritic vitamine in wheat and corn kernel. Am. J. Physiol., 1919, xlviii, 504.

VOEGTLIN, C., AND MYERS, C. N.: J. Pharmacol. and Exp. Med., 1919, xiii, 301.

VOEGTLIN, C., NEILL, M., AND HUNTER, A.: The influence of vitamines on the course of pellagra. Bull. U. S. P. H. Hyg. Lab., 1920, No. 116.

VOEGTLIN, C. AND MYERS, C. N.: Distribution of the antineuritic vitamine in the wheat and corn kernel. J. Biol. Chem., 1920, xli, p. x Proc.

VOEGTLIN, C., AND WHITE, G. F.: Can adenine acquire antineuritic properties? Pharmacol. and Exp. Therap., 1916, ix, 155.

VOEGTLIN, C., LAKE AND MYERS: The dietary deficiency of cereal foods with reference to their content in antineuritic vitamine. U. S. P. H. Reprints xxxiii, 647, 1918.

VOEGTLIN, C., AND HARRIES, R. H.: The occurrence of pellagra in nursing infants in the observations on the chemical composition of the human milk from pellagrous mothers. Bull. 116, U. S. P. H. Hyg. Lab., 1920.

WALSCHE, F. M. R.: The nervous lesions of beri-beri. Med. Sci. Abstr. & Reviews, 1920, ii, 41.

WASON, ISABEL: Ophthalmia associated with a dietary deficiency in fat- soluble vitamine A. J. Am. Med. Assn., 1921, lxxvi, 908.

WEILL, E., AND MOURIQUAND, G.: Compt. rend. Soc. de biol., 1917, lxxx, 33; 1918, lxxxi, 432 & 607.

WEILL, E., AND MOURIQUAND, G.: Recherches sur le scorbut experimental. J. Physiol. et Path, gen., 1918, xvii, 849.

WEILL, MOURIQUAND ET PERRONET: Compt. rend. soc. biol., 1918, lxxxi, June 8.

WELLS AND EWING: Cotton seed meal as an incomplete food. J. Biol. Chem., 1916, xxvii, 15.

WHEELER: Protein free milk factor. J. Exper. Biol., 1913.

WHIPPLE, B. K.: The water-soluble B in cabbage and onion. J. Biol. Chem., 1920, xliv, 175.

WILDIER: Bios requirement of yeast. La Cellule, Lierre et Louvain, 1901, xviii, 313.

WILCOCK, E. G. AND HOPKINS, F. G.: The importance of individual amino acids in diets. J. Physiol, 1906, xxxv, 88.

WILLIAMS, R. J.: A simple biological test for vitamines. J. Biol. Chem., 1919, xxxviii, 465.

WILLIAMS, R. J.: A quantitative method for the determination of vitamines. J. Biol. Chem., 1920, xlii, 259.

WILLIAMS, R. J.: Vitamines and yeast growth. J. Biol. Chem., 1921, xlvi, 113.

WILLIAMS, R. R.: Progress in the investigation of vitamines. Ph. J. Sci., 1915, x, 13, 95.

WILLIAMS, R. R., AND SALEEBY: Experimental treatment of human beri-beri with constituents of rice polishings. Ph. J. Sci., 1915, x, B, 99.

WILLIAMS, R. R., AND CROWELL: The thymus gland in beri-beri. Ph. J. Sci., 1915, x, B, 121.

WILLIAMS, R. R., AND JOHNSTON: Miscellaneous notes and comments on beri- beri. Ph. J. of Sci., 1915, x, B, 337.

WILLIAMS, R. R.: The chemical nature of the vitamines. I. Antineuritic properties of the antineuritic substances. J. Biol. Chem., 1916, xxv, 437.

WILLIAMS, R. R., AND SEIDELL, A.: The chemical nature of the vitamines. II. Isomerism in natural antineuritic substances. J. Biol. Chem., 1916, xxvi, 431.

WILLIAMS, R. R., AND SEIDELL, A.: The chemical nature of the vitamines. III. The structure of the curative modifications of the hydroxypyridines. J. Biol. Chem., 1917, xxix, 495.

WILTSHIRE, H. W.: Value of germinated beans in the treatment of scurvy. The Lancet, London, 1918, ii, 811.

WRIGHT, A. E.: Scurvy and acidosis. Army Med. Dept. Report, 1895-96, xxxvii, 394.

WOOD, E. J.: Pellagra. Edinburgh Med. J., xxv, 363 (1920).

WOOD, E. J.: The diagnosis of pellagra. Arch. Diagnosis, N. Y., 1917, April.

ZILVA, S. S.: The extraction of the fat-soluble factor of cabbage and carrot by solvents. Biochem. J., 1920, xiv, 494.

ZILVA, S. S.: The action of ozone on the fat-soluble factor in fats. Biochem. J., 1920, xiv, 740.

ZILVA, S. S., AND STILL, G. F.: Orbital hemorrhage with protopsis in scurvy. Lancet, London, 1920, i, 1008.

ZILVA, S. S., AND WELLS, F. M.: Changes in the teeth of guinea pigs on a scorbutic diet. Proc. Roy. Soc., ex, B, 505 (1919).

ZILVA, S. S.: The action of the ultra-violet rays on the accessory food factors. Biochem. J., 1919, xiii, 164.

ZILVA, S. S.: The action of deficient nutrition on the problem of agglutinins, complement and amboceptor. Biochem. J., 1919, xiii, 172.

ZUNTZ, E.: Les facteurs accessories de la croissance et de l'equilibre. Scalpel, 1920, June 19, No. 25.