Part 31

INJECTION INTO THE PERITONEAL CAVITY.

These experiments were carried out on full-grown and on young subjects. As in previous experiments, doses of different sizes were employed. A dose of 0.2 gram per kilo was tried first and then reduced gradually to 0.1 gram per kilo.

Cat 10. Female. Weight, 2,970 grams.

October 9, 1909: 1.30 p. m., 30 cc 2 per cent caffein (0.2 gram per kilo) injected into the peritoneal cavity; urine examined for albumin and sugar, negative; cat found dead at 2.30 p. m. No urine in the bladder.

Cat 16. Black female. Weight, 2,420 grams.

October 9, 1910: Urine examined for albumin and sugar, negative; 2.30 p. m., 22 cc 2 per cent caffein (0.183 gram per kilo) injected into the peritoneal cavity; found dead at 3 p. m.

Cat 99. Well-fed gray female. Weight, 3 kilos.

June 22, 1911: 3.40 p. m., 15 cc 2 per cent caffein injected into peritoneal cavity; salivation and marked irritability within one hour after injection.

June 24: Alive, appetite good.

Cat 98. Well-fed black male. Weight, 4,100 grams.

June 22: 3.45 p. m., 20.5 cc 2 per cent caffein (0.1 gram per kilo) injected into peritoneal cavity; very irritable a few minutes after injection, no other symptoms.

June 24: No symptoms, appetite good.

Cat 93. Black and white. Weight, 1,450 grams.

June 22: 3 p. m., 30 cc 2 per cent caffein (0.137 gram per kilo) injected into peritoneal cavity; salivation, no other symptoms; under observation until 6 p. m.

June 23: 9 a. m., no urine, cat showed no symptoms.

June 24: 9 a. m., no symptoms, took nourishment as usual.

Cat 87. Well-fed white female. Weight, 2,615 grams.

June 23: 2.45 p. m., 19 cc 2 per cent caffein (0.145 gram per kilo) injected into peritoneal cavity; became irritable and restless.

June 24: 9 a. m., no symptoms, took nourishment as usual.

Cat 97. Gray. Age, 3 months. Weight, 500 grams. Diet, meat.

June 24: 2.25 p. m., 5 cc 2 per cent caffein (0.2 gram per kilo) injected into peritoneal cavity; 4 p. m., no symptoms.

June 29: Died.

Cat 96. Gray and white. Age, 3 months. Weight, 575 grams. Diet, meat.

June 24: 2.20 p. m., 4 cc 2 per cent caffein (0.139 gram per kilo) injected into peritoneal cavity; 3.55 p. m., no symptoms.

June 30: Died.

Cat 95. Black. Age, about 3 months. Weight, 860 grams. Diet, meat.

June 24: 10.15 a. m., 8.6 cc 2 per cent caffein injected into peritoneal cavity, salivation immediately after injection; 10.25, convulsions and paralysis; died 10.45 a. m. Autopsy: Macroscopical examination of the organs, negative.

Cat 94. Black and white. Weight, 790 grams. Age, about 3 months. Diet, meat.