Part 24

The ophthalmia may be treated by a moist atmosphere, a few drops twice daily of a solution of atropine beneath the lids, a similar treatment with pyoktanin, (1:1000), or a solution of mercuric chloride (1:2000).

In case of gastro-intestinal inflammation elimination is to be sought by ⅓d the usual laxative dose, supplemented if need be, by injections. Half a pint of olive oil with 20 grs. calomel will usually be well borne. Counter irritants may be applied to the abdomen, and the bowels must be carefully watched and any inactivity or derangement corrected. A slight diarrhœa is not to be too hastily checked as it may serve at once to eliminate offensive matters and subdue mucous inflammation. Solutions of flax seed, gum, or slippery elm in the drinking water may serve a good end.

In case of cardiac weakness with intermittent or irregular pulse, hurried breathing, and an undue contrast between the violence of the heart action and the weakness of the pulse, circulatory stimulants are called for. Digitalis 10 grains twice daily, strophanthus tincture 1½ dr., strophanthin subcutem ¼ grain, caffeine 5 grains, veratrine ⅒th grain, or strychnia 2 grains.

Nervous symptoms will exceptionally demand the application of cold water or even ice or snow to the head, with counterirritants to the sides of the neck or chest, and the internal use of bromides, iodides, chloral or other nerve sedative.

Other complications must be treated according to their indications.

As the skin becomes cooler and more moist, and the pulse slower and fuller, a tonic and stimulating treatment may be desirable. Gentian 4 drs., saltpeter 4 drs., sal-ammoniac 2 drs. may be given night and morning, or in case of great debility ammonia carbonate may replace the sal-ammoniac. Or the gentian may be replaced by nux vomica, and the ammoniacal preparations by alcoholic ones.

When prostration becomes extreme and stimulants and bitters appear inadequate, transfusion of blood from a healthy horse may save the patient’s life, or a normal salt solution sterilized may be introduced into the vein.

The first method is accomplished through a caouchouc tube with a short tube of silver inserted in each end; the jugular groove of each horse is washed and disinfected, and the vein opened; the tube disinfected with a salicylic acid solution, and cleared out with boiled water is inserted upward into the vein of the sound horse, and when the blood begins to flow the other end is inserted downward into the vein of the sick one. In this way the blood is allowed to flow from the one to the other, the finger being kept on the pulse of the patient to detect any faltering, which like heaving up of the head or rolling of the eyes, may be taken to indicate undue arterial tension, or disturbed brain circulation, and should be the signal for an arrest of the flow. To effect this, pinch the tube in the centre, and wait a minute or so; if the symptoms subside the current may be reopened and a little more carefully admitted, but if not the tube may be withdrawn and the wounds pinned up.

The normal salt solution, .6 per cent., is sterilized by boiling, and placed in a sterilized vessel where it is allowed to cool to the body temperature; then a caouchouc tube furnished with a silver tube at one end and sterilized as for transfusion of blood, is filled with the solution and the vessel containing the latter having been placed at a level higher than the patient, the tube is used as a syphon. When the liquid flows in full stream the silver tube is inserted downward into the jugular of the patient and the liquid is allowed to flow in, subject to the same precautions as regards sudden blood tension as in the case of the transfusion of blood.

Prevention. No country appears to have attempted the absolute exclusion of the disease or the extinction of the germ by a compulsory quarantine and disinfection. The nearest approach to this is in Prussia where in the event of an outbreak of equine influenza, the official veterinarians and police authorities must send in reports to be published in the official papers and communicated to the directors of government breeding studs and to the army authorities. We have here the germ of an effective system of extinction, for if those in charge of government horses in an infected country can protect them against infection, much more could such protection be secured by putting an end to the infection which is now allowed to remain generalized. Moreover in our great outbreak of 1872–3, when germ-potency and all but universal susceptibility were so remarkable, effective quarantine showed the most signal successes, in the resulting immunity of Vancouver’s Island, Prince Edward Island, the whole of the West Indies except Cuba, Central and South America, and isolated districts in Mexico.

Sanitary police in this disease has been abandoned mainly because the virus is so diffusive on the air that quarantine must be more than usually comprehensive to prevent extension of infection, and because the disease is fatal only in a small percentage of cases, so that the loss is apparently minimized. But a panzoötic like that of 1872–3, prostrating 1,000,000 horses, asses and mules in the United States for one to two weeks, and paralyzing the agriculture and commerce of the continent for that length of time, may well make one hesitate to supinely accept for all time an evil, which, experience has shown, can be circumscribed and stamped out. When horse owners, legislatures and veterinarians can be educated up to the needs of the case our yearly local losses from equine influenza, and the occasional all pervading epizoötics of this disease can probably be abolished by the extinction of the germ on the Continent. To achieve this result an immediate large outlay would be well spent. In a new generation, or a new century perhaps, this desirable object may be achieved.

Meanwhile the individual owner can do something to secure a partial protection. On farms and in barracks the animals may be secluded from all other equine animals during the local prevalence of the disease. Men, dogs, and wild animals can be similarly excluded. Litter, fodder, bags, clothing, manure, vehicles, etc., from infected stables and places must be carefully guarded against. Newly purchased animals, carried in any public conveyance, or kept or fed in any public yard or stable must be quarantined at a considerable distance from others, and treated by disinfectant sponging and fumigation before they are allowed to mingle with other equine animals. Stables where the disease has occurred must be thoroughly disinfected, together with all manure made during the epizoötic and for some time thereafter.

EPIZOOTIC CELLULITIS: PINK EYE.

Williams follows a popular fashion in describing under the above names an affection which may be only a form of equine influenza, but which may be named by itself until its true place can be defined by proof of its actual pathogenic microörganism.

Beside the general constitutional disturbance, this condition is distinguished by marked hyperthermia (103° to 104°), swollen, congested, watering eyelids, cough, strong pulse becoming gradually feeble, firmly coagulating blood, irritable bowels, painful passage of fæces, and, above all, a frequent movement of the feet indicative of discomfort and followed by swelling, often excessive, of the limb or limbs, by a cutaneous and subcutaneous exudate. These various phenomena may all be but manifestations of the rather protean disease, equine influenza, and the cellulitis but variations of the rheumatoid and arthritic forms which are so common in the regular type of that disease in cold or wet climates, or seasons. Williams claims that a prominent danger is the formation of clots in the heart and large vessels and advocates the free use of the salts of ammonia and potash with stimulants. The treatment does not essentially differ from that of equine influenza except in the call for special applications to the inflamed eyes and infiltrated limbs.

PETECHIAL FEVER. ACUTE HÆMORRHAGIC—ANASARCOUS—TOXÆMIA.

Synonyms. Definition. Causes, obscure, bacteria variable, pus microbes no active contagion, toxic products, any toxin causing vaso-dilatation, examples, toxins from fermenting ingesta, debility; impaired innervation, nutrition and function; gravitation; primary and secondary forms: predisposing diseases. Lesions: petechiæ and slight blood extravasations in skin, subcutis, mucosa, submucosa, serosæ, and solid tissues, largest in soft tissues; round cutaneous swellings one to two inches across, patches, cracks, oozing, fissures, sloughs, section shows yellow serous and blood infiltrations, capillaries greatly dilated, infiltrated thickened mucosæ, blocked nasal passages, ulcers, serous and bloody discharges, pharynx, larynx, lungs, stomach, intestines, kidneys, blood firm or diffluent. Symptoms: Hyperthermia, nasal petechiæ, extravasation, pink or yellow oozing, swellings on nose, lips, face, limbs, oozing, cracks, sloughs, turning up of toe from detachment of the flexors, metastasis from skin to lungs, or abdomen, dyspnœa, colics, serous or bloody diarrhœa. Course. Duration: acute two days, average one to three weeks, tardy one to two months, Diagnosis: from glanders, anthrax, urticaria, malignant œdema, horse pox. Mortality. Prognosis: 50 per cent.: hopeless and grave indications. Sudden retrocession. Treatment: excellent sanitary conditions, cleanliness, air, light, green food or mashes, pure water, laxative food, or salts, diuretics, alkaline diuretics, vaso-motor contractors, antiseptics, quinine, strychnine, phenic acid, lysol, ichthyol, sulphites, etc.; locally aluminium acetate, cold water, scarification, nasal injections and tubes, tracheal iodine injections, argentum colloidale intravenously, antistreptococcic serum subcutem, Menveux’s solution.

Synonyms. Purpura Hæmorrhagica; Morbus Maculosus; Anasarca (Fr.); Typhus: Anthrax; Dropsy of Connective Tissue; Mal de Tete de Contagion; Coryza Gangrenosa; Malleus Gangrenosa; Charbon Blanc; Diastashemia; Leucophlegmasia.

Definition. An acute (or subacute), toxæmic, generally secondary disease, manifested by capillary dilatation and petechiæ on the mucosæ, skin, serosæ and elsewhere, and attended by extensive effusions of lymph and blood into the skin and connective tissue, to form hot, tender, nodular, diffused, or general swellings.

Causes. The causes of petechial fever are not clearly made out. Bacteria are found in the early exudate, but these are not constant in kind and it is not unreasonable to suspect that these may be results rather than causes of the lesions. On the other hand there may be an as yet undiscovered organism present, the products of which are capable of producing the disorder. Or the latter may be due to a combination of the toxins of two or more. Among the bacteria found may be named: The pus microbes, cocci, streptococci, staphylococci, and bacilli, have been found and adduced as causes, also diplococci, the bacillus hæmorrhagicus of Kolb, the streptococcus of strangles, the microörganism of contagious pneumonia and that of influenza, with a variety of others too great and too inconstant to be accepted as proof of cause. The fact that rarely more than one animal suffers in the same stable at the same time might be held to oppose the idea of contagion and of a definite organized germ.

Hence the theory of its causation by the presence in the system of the toxic products of bacteria rather than the bacteria themselves. (Dieckerhoff.) Cadeac supposes that any toxin which causes capillary dilatation may determine the disease, and calls attention to the fact that the injection of mallein (a vaso-dilator) aggravates the phenomena of petechial fever and determines enormous local exudations and engorgements. He notes further the potent vaso-dilator action of the products of strangles, contagious pneumonia, and influenza which are among the most frequent antecedents of petechial fever. Dieckerhoff also looks on the phenomena as the result of poisoning by the absorbed toxins of the microbes of suppuration, which modify the nutritive changes in the walls of the capillaries and determine exudations and hæmorrhages. Zschokke thinks that there is infection of the intima of the capillaries, with the formation of coagula. Clots are not found, however, apart from hæmorrhages.

The toxin theory receives indirect support from the absence of the same specific lesions in simple mechanical congestion of the capillaries and veins. Ranvier had no such results from tying the veins of a rabbit’s ear. Roger tied the auricular veins of the rabbit, and then cut the sensory nerves without effect: he then destroyed the cervical sympathetic ganglion, when there supervened marked exudation, lasting for three days. The complete blocking of veins by pressure or aseptic ligature, does not produce a spreading œdema, whereas in ordinary suppurative phlebitis, with abundance of toxins in the tissues this is a constant result.

The toxin theory does not fully account for those cases that occur suddenly, without any manifest pre-existing disease, and as the result apparently of cold and chill. On the other hand, it is only a very small proportion of horses exposed to the same degree of cold and chill that contract petechial fever, and it might well be surmised that in these few an unknown focus of suppuration or other lesion existed prior to the chill or that toxins having the requisite devitalizing and vaso-dilating properties had been absorbed from fermentations in the bowels or elsewhere. The mere exposure is harmless to the very great majority of subjects.

In any case it must be accepted that the debility and impaired local innervation, nutrition and function, that attend on the exposure to cold and toxins must be looked on as potent contributing causes. The predilection of the swellings for dependent parts (limbs, venter, face) shows the influence of gravitation and congestion. Whether there is present any special microbe which has yet eluded discovery, but which is the main pathogenic factor, must be left to the future to decide.

In cases that appear to be due to cold or chill alone, the disease is held to be primary; in those following on another affection, secondary.

Among the diseases on which petechial fever supervenes as a secondary affection contagious inflammatory affections of the lungs and air passages hold a bad preëminence. Strangles, influenza and contagious pneumonia, about in the order named, are especially causative factors or occasions of petechial fever. Among the other affections on which it supervenes may be named pharyngitis, abscess of the nasal sinuses, hepatic, renal and other internal abscesses, acute coryza, laryngitis, or bronchitis, enteritis, abortion, aggravated grease, suppurating wounds of the skin, infective abrasions by harness, suppurating sores after firing, infective arthritis with open joint, amputation of the tail, and castration.

Lesions. In certain cases these may be largely confined to petechiæ and slight blood extravasations, which are distributed very generally throughout the tissues, but show especially in the skin, subcutis, mucosa and submucosa of the nose, eyes, pharynx, guttural pouches, larynx, trachea, bronchia, mouth, stomach, intestine, bladder, vagina and womb; also in and on the lungs, pleura, pericardium, heart, liver, spleen, kidneys, peritoneum, pancreas, ovaries, bones, lymph glands, brain and nerves. The largest extravasations are liable to be in the softest tissues, and in the lungs they may reach the size of the closed fist, though usually they vary from a mere spot up to this. The spleen is sometimes engorged even to rupture. Beside the extravasations, and associated with them in position, and probably largely as an effect of them, there is more or less serous effusion infiltrating the tissues, congestions, suppurations, degenerations, and necrotic changes.

The skin, if white, and the dark skins on section, are seen to be marked by petechiæ. The cutaneous swellings may appear on any part, commencing with nodular thickenings varying in size from a pea to a walnut, and merging together into extensive elevated areas terminating abruptly at their margins in the smooth skin. The larger and more persistent engorgements settle on the lower aspect of the body and other dependent parts like the limbs and face. Cracks, oozing, deep fissure, and extensive sloughs are not uncommon. When the skin is incised it shows serous infiltration and thickening, with spots and patches of blood extravasation. The subcutaneous connective tissue is similarly infiltrated and discolored, and often in the limbs, face, and under the breast, sternum and abdomen so as to form a tremulous gelatinoid cushion of several inches in thickness. The capillaries may be distended to more than 20 times their normal calibre. The exudate may extend deeply between the muscles, and sloughs may lay these freely open and invade their substance. The muscular tissue is mottled with petechiæ, and apart from these it is pale, yellow, or grayish, having to some extent undergone granular or fatty degeneration. Detachment of the perforans and perforatus from their insertions is occasionally met with.