Part 21

The MS. of Manfredi’s Anatomy is in the Bodleian Library at Oxford (Canon. Ital. 237, Western 20287). It is a fairly preserved small quarto parchment, originally of forty-nine folios, of which the third and fourth are missing. The writing is in the fine Italian hand that the printed type of the period was accustomed to imitate. There are no figures or illuminations, but the titles are rubricated in burnished gold or in colours.

There is no reference to this work in any account of Manfredi, and the volume itself appears to be quite unknown. Neither the man nor his work is mentioned in Medici’s detailed history of the anatomical school at Bologna nor in Martinotti’s recent study on the same topic, nor is any MS. of Manfredi included in Mazzatinti’s monumental catalogue of the MSS. in the Italian libraries.

Manfredi’s MS. is written in the involved Italian of the day, with sentences of inordinate length. These general characters of style are encountered also in his published works. The dedication is in Latin, of the same unpleasing quality, and is couched in the usual subservient manner. It is addressed to Giovanni Bentivoglio, and in it Manfredi relates that

‘Your illustrious lordship Johannes Bentivolus in this present year 1490 with your usual humanity condescended on one occasion to watch the dissection of a corpse.... It was then that you saw the wonderful works of Nature in the anatomy ... and you parentally urged me, Hieronymo Manfredi, to inscribe to your most noble name this work on anatomy.... I therefore extracted this work as best I might from various works of antiquity and abbreviated it. I have not followed their order, but I have so composed it that the work should be pleasing to your lordship.

‘Accept then, O great and powerful lord, this work on the anatomy of the human body inscribed to your noble name! Accept it with your customary benevolence and humanity and in a kindly and gracious spirit, for it will be pleasing to you and will delight you greatly, for it is a worthy work!’

The Giovanni Bentivoglio (Plate XXXVII), with adulation of whom Manfredi was thus accustomed to plaster his works, was the second of the name and was the son of Annibale Bentivoglio. In the year 1462 he became head of the republic of Bologna, and played there much the same rôle as did Lorenzo de’ Medici at Florence. He adorned Bologna with numerous buildings, and acted as patron of the arts and the sciences. The Palazzo dei Bentivogli still stands as a memorial to him and his family. A stern and high-handed tyrant, he held his position until 1506, when he was expelled and the city reverted to the papacy. He died two years later.

It is remarkable to find a man of Bentivoglio’s eminence and position taking an interest in the practical study of anatomy. Other Italian rulers, Lorenzo de’ Medici among them, encouraged and legalized the practice of dissection, but probably Bentivoglio is the only one recorded as having patronized an ‘anatomy’ in person. The interest taken in the subject by the heads of states must have been of great value to the artists whose patrons they were.

The MS. is a unique copy, and was doubtless written for presentation to Bentivoglio. That it was never printed is perhaps due to the fact that Manfredi died within a comparatively short time of its composition. It represents the most satisfactory post-mediaeval account of the human frame until the appearance of the work of Berengario da Carpi in 1521. It is more complete than the work of William of Saliceto or of Mondino or the anatomy erroneously attributed to Richardus Anglicus; it is more natural than the book of Gabriele de Gerbi, and is far superior to the crude contemporary sketches of Hundt, Peyligk, and Achillini, while it wastes less space than Guy de Chauliac on teleology, though it has none of the charm of the work of that great surgeon. In one respect at least, viz. the spirit in which it is written, Manfredi’s Anatomy is original and probably unique for its age. There is no reason to doubt the assurance of the dedication that it was composed for the edification of the tyrant of Bologna, and for the simple purpose of setting forth the wonderful structure of man’s body without thought of any medical application.

The sources of the MS. are obvious. It is in the main a rearranged and on the whole improved Mondino, but amplified by reference to translations from Galen, Rhazes, Haly Abbas, and Avicenna. Guy de Chauliac has perhaps also been used. The work gives a general impression of being the product of a practical dissector, and it provides us with a good example of early Renaissance anatomy as taught in the Italian schools before the reforms of Vesalius. It is perhaps the first complete treatise on its subject written originally in the vernacular. It exhibits, however, no other original features nor any considerable departures from its sources, and it may be taken to represent, with but little modification, the tradition of Mondino as developed at his own University of Bologna at the end of the fifteenth century.

Manfredi’s work, however, if not original is at least eclectic, and the variety of its sources indicates a dawning consciousness of the unwisdom of trusting to the infallibility of any one writer. The work is thus in a sense intermediate between the early printed versions of Mondino, such as that of 1478, and the edition published in 1528 by Berengario da Carpi with its frank commentary of the master. All represent stages towards the freedom of the later Renaissance investigators.

We reproduce the text in full, and the passages on the head, on the eye, and on the heart, are rendered into English. All are similar to the accounts of Mondino. We are able to illustrate them by figures from contemporary works, and thus to give an idea of the limits of the anatomical knowledge of the day.

V. TRANSLATION OF SELECTED PASSAGES FROM THE ANATOMY, WITH COMMENTARY

(a) THE HEAD

Tractate i, Chapter 2

(folio 5 verso) There are ten layers of the head.

The first is the hair made by nature for the better protection of the head from external things, and also for beauty.

The second part is the skin, which has here to be very thick, so that the hair may be firmly embedded, having its roots thick and long; and also to be a better shield and covering for the bone and brain, since there is no muscular part here.

The third part is the flesh, developed only on the face, the temples, and about the jaws, not on the other parts.

The fourth part is an external membrane called almochatim [Arabian term for cranial periosteum] which, when the skin is raised, appears to be continuous and covers the whole cranium. And nature made this membrane firstly so that the skin which is soft should not come into contact with the hard bone, secondly that the bone of the head should have sensation through it, and thirdly that the internal membrane of the head, called dura mater, should, by means of this membrane, be attached to the bone of the cranium by certain nerves and ligaments. These, issuing through the commissures of the bones, have thus their origin in the aforesaid internal membrane, while on emerging through the bone, they weave themselves into or rather compose the external membrane called almochatim.

The fifth part is the skull. This is a bone like a cap, inside the cavity of which is located the brain. In the skull are four bones sutured together. Nature made the skull not of one but of many pieces, firstly, so that if harm should fall on one part it might not spread to the others; secondly, so that by their joints or rather sutures [Italian cusiture=sewings], the humours of the brain might be the better exhaled; and thirdly, so that when there is need of applying medicines, these might the better penetrate to the parts within.

Hence it is that four pieces of bone are sutured and joined together by nature in a denticulate fashion, so that they might be the firmer and stronger. Nor are they bound with ligaments as are the joints, for these would not have been so strong, and furthermore the bones of the head do not need to move.

These sutures are five in number, three being true and two false. The true sutures are those which pass right through the bone, while the false do not. Of the true sutures one is in the anterior part and is called coronal; it is made like the letter C, and stretches from right to left of the head, the two wings of the C being directed towards the forehead. The second true suture extends along the length of the head, beginning from the coronal and reaching the back part of the head. It is like a shaft or rather arrow that goes backwards from the brow, wherefore it is called sagittal ----(. The third true suture is in the posterior part and is called laudal, for it is made like a Λ, the letter called by the Greeks lauda. The sagittal suture extends from the coronal to the lauda ❯----(.

The false sutures are two, one on each side. They are called cortical because they do not penetrate.

Now if we consider these five sutures we shall see that there are four bones articulated together. One is the forehead bone [frontal] which begins at the coronal and ends below at another suture, which itself begins as a branch of the coronal suture and proceeds by way of the eyebrow to the corresponding branch [of the other side] Ɑ.

A second bone is behind and terminates at the laudal suture. There are two other bones which form the temples. These terminate at the false sutures which themselves begin at the laudal and end at the coronal suture.

The sixth part [of the head] consists of two membranes. One of these is called dura mater, and lies in contact with the cranium. The other is called pia mater and is in contact with and covers the brain. And nature contrived it thus, having great solicitude for this latter member, that while close to the bone, it should yet not be touched by it. Wherefore, taking due precautions, she made the one [membrane] harder than the other. Furthermore she made two membranes, so that if harm befell one of them, it might not be communicated to the underlying brain.

In the pia mater are woven certain veins by which the brain is nourished. [The brain is] everywhere covered by it except on the posterior part; because this part being dry, it has no need of this membrane, as have the anterior and middle parts. The two membranes in many places penetrate the substance of the brain, dividing it into a right and a left, a front and a back section. By this division, divers cells or rather small chambers are made therein, in which the soul (anima) performs its divers operations, for which reason it is necessary that these parts should be of different structure.

When the two membranes are raised, the seventh part of the head, namely the brain itself, appears. The brain is wrought by nature so that the vital spirit from the torrid heart should be tempered by its cold, for here it is converted into animal spirit, which is the beginning of the perceptive (cognoscitiue) and motive processes.