Part 20

Case 48 is related by Mr. Paget as follows. “I am anxious to place before the profession, at the earliest opportunity, a narrative of a case in which chloroform proved fatal in my private practice.

“The patient was a boy, nine years old, of delicate constitution, and of nervous, timid disposition; but with no indication of any organic disease, except that for which the operation was to be performed: namely, a tumour of the scapula; for which it was proposed to remove the greater part of that bone.

“At half-past eight A.M., on February 28th, after the patient had passed a night of sound sleep, the chloroform was first administered in a room adjoining that in which the operation was to be performed. He was alarmed at the thought of being put to sleep, and of what would then be done, and was very averse from taking chloroform, but he was persuaded to inhale it; and, though not without resistance, yet with less than is commonly made by patients of the same age, he was brought under its full influence in about three minutes. He sat in bed during the first few inspirations, and after these, was recumbent. It was observed that two or three deep inhalations were quickly followed by complete insensibility; and the next few inspirations were stertorous. He was at once carried, in the horizontal posture, into the room, and laid on the table, arranged for the operation.

“Three or four minutes passed while we were arranging his position and his dress, and while I was pointing out to those who were to assist me the proposed plan of operation. During this time the influence of the chloroform so far passed off, that he became sensible, displaced his coverings and pillows, said something expressive of discomfort, and vomited a small quantity of frothy fluid. (He had taken no food since the previous night, when he had had a good supper.) A very small quantity more of chloroform was slowly inhaled, and he became again nearly quiet, and was again placed on his side. I was on the point of commencing the operation, but as he again, by movements, indicated some degree of sensibility, and changed his posture, about forty drops more of chloroform were poured on cotton wool, inclosed in a fold of lint,—an inhaler, with the chloroform on sponge, having been previously used. The lint was held, about half an inch from the face, by Mr. Thomas Smith, my usual assistant in operations. The patient inhaled lightly for a few times, then made one long inspiration, and appeared to pass at once into deep sleep. Except that he thus appeared to come suddenly under the full influence of chloroform, no external change was visible; but, a few seconds later, his pulse, which had been carefully watched, and had been to this time normal, suddenly began to beat very quickly; then it ceased for two or three seconds; then beat rapidly several times, with a kind of flickering movement; and then ceased to be perceptible.

“Just before this change of the pulse was observed, the chloroform had been withdrawn. The one deep inspiration was followed by a few stertorous breathings, but after these he breathed naturally, his complexion and features showed no change, he seemed only calmly asleep, and in this state he continued breathing naturally, and with no change in his appearance, but pulseless, for at least a minute. Then his breathing became less frequent, and seemed as if it might soon cease; his face grew pale, and his lips very slightly livid.

“With the help of cold water sprinkled on his chest and face, and cold air blown on his face and throat, he was raised from this state of defective breathing in about two minutes, and again breathed deeply and freely, though slowly, (probably about twelve times in the minute.) He thus breathed for two or three minutes, and during this time the lips, and the pale or slightly livid parts of the face, became pink again, and though no pulse could be felt at the wrists, the heart was heard acting. During this time, also, some wine and brandy were poured into the mouth, and passed down the œsophagus, but without any evident movements of swallowing. His breathing again became gradually infrequent and feeble. Cold air and sprinkling with water, frictions and percussions of the chest, scarcely increased the breathing, and in less than two minutes it ceased. Artificial respiration, by the method of Dr. Marshall Hall, was immediately employed, and many times during the first five minutes of its employment the artificial inspiration obtained, when turning the body over to its side, was followed by a distinct, and sometimes even a full muscular inspiration. But at the end of about five minutes, these signs of life ceased, fæces escaped, and no more indications of life appeared, though the artificial breathing, the friction of the limbs, and other means for resuscitation, were continued for twenty or more minutes.

“I refrain, at present, from all comments on this case. Only, I wish to call particular attention to the fact that good breathing was maintained, and, after a suspension, was renewed, long after the heart had ceased to act with sufficient force to produce a pulse at the wrist. And I would add, that this narration is sanctioned and considered to be exact, by the four gentlemen who were to have assisted in the operation, and to whom I am greatly indebted for their counsel and assistance in the greater difficulty that we had to cope with.”

Case 49. This case occurred in the Liverpool Infirmary on April 5, 1857, and is related by Mr. Allan, the resident officer who administered the chloroform. The subject of the case was a labourer, aged 35, on whom Mr. Bickersteth was about to perform amputation of the thigh on account of gangrene following the ligature of the femoral artery. He had inhaled the chloroform six days previously without ill effects, when the femoral artery was tied for popliteal aneurism. On the day of the accident, he was first rendered insensible in the ward by chloroform poured on a piece of lint which was held a short distance from the nose and mouth. Having partially recovered during his removal into the operating theatre, the chloroform was reapplied, and Mr. Allan relates what occurred as follows: “About half a drachm of chloroform was now poured on some lint, which was held to the nostrils, and he then became fully under the influence; respirations good; pulse frequent, feeble. The operation was about to be commenced, and I was pouring about twenty minims more chloroform on the lint, (having pronounced the patient to be in a fit state,) so as to be ready to give him some more as occasion required, but had not applied it, when, turning round, I noticed something peculiar in his general appearance, and, on lifting up the eyelid, found the pupil dilated, and the lid did not close over on the removal of the finger; the eyes were slightly turned up. I at once felt for the temporal artery, but there was no pulsation, and none detected at the left wrist; the respirations had almost ceased. The head was lowered, cold water was dashed on the face, and the abdomen struck with the palm of the hand; the finger thrust into the mouth (there was no action of the heart felt); the legs were elevated, and a wet towel was dabbed over the epigastrium. After one or two blows, the respirations became better, and seemed good, and in about two minutes a pulse was felt at the wrist. This continued between two and three minutes, the respiration being good. His pulse then began to fail, and in about a minute more the respirations were less. The tongue was seized with a pair of forceps, and drawn forwards, and artificial respiration tried, and ammonia held to the nostrils; but he was becoming livid in the face, so the Ready Method was at once adopted, and this produced apparently a few natural respirations. But the pulse had gone, and in about two minutes more there was no breathing save artificial. About the time that the pulse stopped, there was a convulsive movement of the muscles of the leg, and a slight clamminess of the skin succeeded. The Ready Method was continued for half an hour, and galvanism tried, but without avail. From the time he was placed on the table to his death, or the cessation of natural respiration, about ten minutes elapsed.”

The writer adds: “He apparently sank from syncope, or cessation of the heart’s action, for his respiration had been good just before he changed, and it continued for a second or two, though faint, when the pulse had stopped; and after the respiration had been restored, and was very good, the pulse was very feeble, and ceased two minutes before the respiration.”

At the autopsy on the following day, the brain was found to be healthy, tolerably firm, and pale; the lungs were healthy; the right cavities of the heart contained some fluid blood, which afterwards coagulated on exposure, and a small clot. The left cavities also contained some blood. The muscular tissue of the heart had an unhealthy look, and very readily tore, but no oil globules were discovered with the aid of the microscope.

Case 50 occurred in King’s College Hospital, August 7th, 1857. The following is the account of the case furnished by Mr. C. Heath, the House-surgeon:—

“The patient [Ann Stoner] was a female, aged seventeen, under Mr. Partridge’s care, with syphilitic warts and mucous tubercles. She was admitted July 8th, and had had chloroform administered twice, in order that the sores might be touched with nitric acid, and, on both occasions, not the slightest ill effect was produced. On Friday evening last, chloroform was again administered for the same purpose; only a drachm was put into the inhaler (Snow’s), and as soon as she became unconscious the inhaler was removed, and the acid applied. I and my assistant (who administered the chloroform), then went to see another patient in the same ward, and then washed our hands, during which time the patient was moving her legs about much as they do when recovering, and in addition she made water over the bed. I gave directions to the nurse to apply a poultice as usual, and left the ward, having been up to the bed first without noticing anything unusual about the patient. In a few minutes the nurse came down for some medicine for another patient, and mentioned that this one was looking very pale: I sent up Mr. Liddon to see her at once; he found her pale and senseless, dashed some water over her, and called me, and I went up immediately. I found her pulseless and cold, and immediately commenced artificial respiration (Marshall Hall), and sent for the galvanic battery; this was brought and applied without effect, and the artificial respiration was continued for twenty-five minutes without the slightest effect being produced.”

I was present at the examination of the body on the following day. The mouth was sore and swollen from the effects of the inunction of mercury. There were a few drachms of clear serum in the pericardium. The heart was large for the size of the patient. There was a patch of organised lymph on the pericardium, covering the left ventricle. The right cavities of the heart were full of dark fluid blood, and the left cavities contained a little. The mitral valve was much thickened, but the other valves were healthy. The lungs were healthy, and not much congested. The brain was healthy. The patient had suffered from acute rheumatism before entering the hospital.

It will be observed that the pulse is not mentioned in the above case, until its absence is alluded to, when the patient was already cold, and the breathing is not alluded to throughout the account; indeed, it is not known when the patient died. She was alive after the application of the nitric acid, as she was observed to move her legs, but further than this there is no clear evidence.

It is perhaps an open question whether this patient died at once from the direct effects of the chloroform, or whether she died after partially recovering and going on favourably for a time. The account would, at first view, seem to favour the latter opinion, but it is not corroborated by any other case. Patients have been partially recovered from the effects of an overdose, without being entirely restored, and others have sunk after great operations, attended with hæmorrhage, when the effects of the chloroform had more or less subsided, but there is no instance of a patient going on favourably, and partially recovering from the influence of the vapour, and then dying suddenly without any other known cause. Patients have occasionally become faint whilst recovering from chloroform, more especially if they remain in the sitting posture, but in those cases the right side of the heart is probably insufficiently supplied with blood; whilst, in the case under consideration, the patient was lying, and the right cavities of the heart were found full after death, the serum in the pericardium showing that they had probably been distended when death took place. If Mr. Heath had made any observation which enabled him to say that the patient was really alive, when he went up to the foot of the bed, before leaving the ward, it would decide the question, and show that death did not take place at once from the direct effects of the chloroform, but he only makes the negative remark that he did not notice anything unusual about the patient.

I had an opportunity of examining the particular inhaler employed, and found that it was so arranged that the vapour might be breathed from it in much greater proportion than would be safe, if precautions were not taken to leave the expiratory valve a considerable way open, especially when the high temperature of the weather at the time is taken into account.

The foregoing cases comprise all the instances I have seen recorded in which death appears to have been occasioned by the administration of chloroform, and not by other causes in operation about the same time. A few additional cases have indeed been referred to by different authors where death was probably caused by chloroform, but as I do not find that the details have been published, I cannot make them available in an inquiry respecting the cause and prevention of these accidents.

In June 1852, Dr. Simpson alluded in the following terms to an accident from chloroform which had occurred near Glasgow:—“In this instance, chloroform was given by the practitioner for tooth extraction; but, I am sorry to add, none of the parties present were at the time in a condition to give any satisfactory evidence.”

A person, named Breton, a dealer in porcelain, died in Paris, in the early part of 1853, immediately after a few inspirations of chloroform, which was administered with the intention of removing a tumour of the cheek. An action was brought against Dr. Triquet and M. Masson for causing death by imprudence in this case; and at the trial which ensued, various interesting opinions were given, and the accused practitioners were ultimately exonerated. I have not, however, met with any record of the symptoms which occurred in the case.

In relating the case of death from chloroform, which occurred in his practice, to the Medical and Chirurgical Society of Edinburgh, Dr. Roberts referred to another death from chloroform in tooth-drawing which took place in the neighbourhood from which his own patient came, just previously to October 1855; but I have not met with any account of the case so alluded to. Dr. Mackenzie of Kelso also alluded in the same Society, in the following year, to a death from chloroform which had occurred at Coldstream, and I do not know whether this was the case to which Dr. Roberts had alluded, or a fresh one.

One of the surgeons to the hospital at St. Louis, who was lately visiting the medical institutions of London, informed me that there had been three deaths from chloroform at his hospital out of between six and seven hundred operations in which it had been administered. I did not learn the particulars of those fatal cases.

There have been several cases in which persons have been found dead after inhaling chloroform when no one else was present, either for toothache or some other affection, but I have not included such cases in the above list, as they throw no light on the way in which death is occasioned. The simple way to avoid such accidents as those just alluded to, is for persons to abstain from inhaling chloroform, when no one is by to watch its effects.

ALLEGED FATAL CASES OF INHALATION OF CHLOROFORM.

Several deaths have been attributed to chloroform which were due to other causes, or where the cause of death is a subject of great doubt. A gentleman, named Walter Badger, twenty-two years of age, the son of one of the coroners for the county of York, died instantly at Mr. Robinson’s, the dentist’s, in Gower Street, on June 30th, 1848, whilst commencing to inhale chloroform with the intention of having some teeth extracted. The inhaler employed consisted of a face-piece to enclose the mouth and nostrils, and containing a sponge on which the chloroform (ʒiss) was placed. This, according to the evidence of Mr. Robinson and his female servant, who was present in the room, was held not nearer than an inch and a half from the face for less than a minute, and the patient made the remark that the chloroform was not strong enough; Mr. Robinson requested him, as he had done before, to have the operation performed without chloroform, but he again declined; and Mr. Robinson then took away the face-piece and asked his servant to reach the bottle, intending to put more chloroform on the sponge, to replace that which he believed had been lost by evaporation. Just after removing the face-piece, and before any fresh chloroform was poured out, the head and hand of the patient dropped, and he did not show any further sign of life.

I found, on making trial of the kind of inhaler which Mr. Robinson employed, that it is impossible to inhale enough of the vapour to produce any appreciable effect, unless it is applied so as to touch the face. At the distance of an inch no effect is produced, even in five or ten minutes; and therefore I expressed my opinion, soon after this accident, that it was not caused by the chloroform, which properly speaking the patient did not inhale.

A consideration of the symptoms in this case confirms the view that the death was not caused by chloroform. In six of the fatal cases related above, death took place instantaneously, without insensibility or any of the usual effects of chloroform having been produced; but the mode of dying was not the same as in Mr. Robinson’s patient. In Case 4, that of Madlle. Stock, the patient said “I choke”, and tried to push away the handkerchief; then there was embarrassed breathing and foaming at the mouth. In Case 11, that of Madame Labrune, the fatal attack followed immediately on a full inspiration of chloroform, and there was an immediate alteration of the features, and a convulsive rolling of the eyes, amongst other symptoms. In Case 14, the young lady stretched herself out, and frothed at the mouth, at the moment of the fatal attack, and the face became livid. In Case 26, that of Madame W., who died at Ulm, the voice, when answering the question about singing in her ears, was trembling and thick; she stretched out her limbs, and the face became bluish. In Case 45, that of the wife of a medical man, and in 46, that of Dr. Roberts’s patient in Edinburgh, there was a convulsive start at the moment of the sudden death. It thus appears that when the heart is suddenly paralysed by an overdose of chloroform, before the patient is rendered insensible, there are usually some symptoms as if of a violent shock or injury. After complete insensibility is induced, the heart may be suddenly paralysed by chloroform, as is shown by numerous cases, without this spasmodic action; and it would perhaps be premature to deny that a patient might die thus quietly without being first made insensible; and the nature of the death in this particular case must be chiefly decided by the physical fact that the patient could not have inhaled enough chloroform to produce an appreciable effect of any kind, much less to cause sudden death.

At the inspection of the body, the liver was found so much enlarged that it weighed eight pounds, and it encroached very much on the chest. The walls of the left ventricle of the heart were found thinner than natural, and the muscular tissue was interspersed with fatty degeneration. There was blood in the right auricle and in both ventricles. In the ventricles it was partly coagulated. The brain presented nothing abnormal.

It is probable that the immediate cause of death in this instance was fear. The patient had been told in the country that it would be unsafe for him to take chloroform, and yet he could not summon resolution to undergo the operation without it. Mr. Robinson unfortunately allowed his patient to remain seated in the operating chair; and it was only when Dr. Waters had been sent for and arrived from a neighbouring street that he was laid on the floor.