Part 23

From what I have observed (says Professor Binz) of recent English publications on the subject of hay fever, I am led to suppose that English authorities are inaccurately acquainted with the discovery of Professor Helmholtz, as far back as 1868, of the existence of uncommon low organisms in the nasal secretions in this complaint, and of the possibility of arresting their action by the local employment of quinine. I therefore purpose to republish the letter in which he originally announced these facts to myself, and to add some further observations on this topic. The letter is as follows: [Footnote: Cf. Virchow's 'Archiv.' vol. xlvi.]

'I have suffered, as well as I can remember, since the year 1847, from the peculiar catarrh called by the English "hay fever," the speciality of which consists in its attacking its victims regularly in the hay season (myself-between May 20 and the end of June), that it ceases in the cooler weather, but on the other hand quickly reaches a great intensity if the patients expose themselves to heat and sunshine. An extraordinary violent sneezing then sets in, and a strongly corrosive thin discharge, with which much epithelium is thrown off. This increases, after a few hours, to a painful inflammation of the mucous membrane and of the outside of the nose, and excites fever with severe headache and great depression, if the patient cannot withdraw himself from the heat and the sunshine. In a cool room, however, these symptoms vanish as quickly as they come on, and there then only remains for a few days a lessened discharge and soreness, as if caused by the loss of epithelium. I remark, by the way, that in all my other years I had very little tendency to catarrh or catching cold, while the hay fever has never failed during the twenty-one years of which I have spoken, and has never attacked me earlier or later in the year than the times named. The condition is extremely troublesome, and increases, if one is obliged to be much exposed to the sun, to an excessively severe malady.

'The curious dependence of the disease on the season of the year suggested to me the thought that organisms might be the origin of the mischief. In examining the secretion I regularly found, in the last five years, certain vibrio-like bodies in it, which at other times I could not observe in my nasal secretion... They are very small, and can only be recognised with the immersion-lens of a very good Hartnack's microscope. It is characteristic of the common isolated single joints that they contain four nuclei in a row, of which two pairs are more closely united. The length of the joints is 0.004 millimetre. Upon the warm objective-stage they move with moderate activity, partly in, mere vibration, partly shooting backwards and forwards in the direction of their long axis; in lower temperatures they are very inactive. Occasionally one finds them arranged in rows upon each other, or in branching series. Observed some days in the moist chamber, they vegetated again, and appeared somewhat larger and more conspicuous than immediately after their excretion. It is to be noticed that only that kind of secretion contains them which is expelled by violent sneezings; that which drops slowly does not contain any. They stick tenaciously enough in the lower cavities and recesses of the nose.

'When I saw your first notice respecting the poisonous action of quinine upon infusoria, I determined at once to make an experiment with that substance, thinking that these vibrionic bodies, even if they did not cause the whole illness, still could render it much more unpleasant through their movements and the decompositions caused by them. For that reason I made a neutral solution of sulphate of quinine, which did not contain much of the salt (1·800), but still was effective enough, and caused moderate irritation on the mucus membrane of the nose. I then lay flat on my back, keeping my head very low, and poured with a pipette about four cubic centimetres into both nostrils. Then I turned my head about in order to let the liquid flow in all directions.

'The desired effect was obtained immediately, and remained for some hours; I could expose myself to the sun without fits of sneezing and the other disagreeable symptoms coming on. It was sufficient to repeat the treatment three times a day, even under the most unfavourable circumstances, in order to keep myself quite free. [Footnote: There is no foundation for the objection that syringing the nose could not cure the asthma which accompanies hay fever; for this asthma is only the reflex effect arising from the irritation of the nose.--B.] There were then no such vibrios in the secretion. If I only go out in the evening, it suffices to inject the quinine once a day, just before going. After continuing this treatment for some days the symptoms disappear completely, but if I leave off they return till towards the end of June.

'My first experiments with quinine date from the summer of 1867; this year (1868) I began at once as soon as the first traces of the illness appeared, and I have thus been able to stop its development completely.

'I have hesitated as yet in publishing the matter, because I have found no other patient [Footnote: Helmholtz, now Professor of Physics at the University of Berlin, is, although M.D., no medical practitioner.--B.] on whom I could try the experiment. There is, it seems to me, no doubt, considering the extraordinary regularity in the recurrence and course of the illness, that quinine had here a most quick and decided effect. And this again makes my hypothesis very probable, that the vibrios, although of no specific form but a very frequent one, are at least the cause of the rapid increase of the symptoms in warm air, as heat excites them to lively action.

I should be very glad if the above lines would induce medical men in England--the haunt of hay fever--to test the observation of Helmholtz. To most patients the application with the pipette may be too difficult or impossible; I have therefore already suggested the use of Weber's very simple but effective nose-douche. Also it will be advisable to apply the solution of quinine tepid. It can, further, not be repeated often enough that quinine is frequently adulterated, especially with cinchona, the action of which is much less to be depended upon.

Dr. Frickhoefer, of Schwalbach, has communicated to me a second case in which hay fever was cured by local application of quinine. [Footnote: Cf. Virchow's 'Archiv.' (1870), vol. li. p. 176.] Professor Busch, of Bonn, authorises me to say that he succeeded in two cases of 'catarrhus aestivus' by the same method: a third patient was obliged to abstain from the use of quinine, as it produced an unbearable irritation of the sensible nerves of the nose. In the autumn of 1872 Helmholtz told me that his fever was quite cured, and that in the meantime two other patients had, by his advice, tried this method, and with the same success. [Footnote: Prof. Helmholtz, whom I had the pleasure of meeting in Switzerland last year, then told me that he was quite convinced that hay fever was produced by the pollen afloat in early summer in the atmosphere.]

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VI. VOYAGE TO ALGERIA TO OBSERVE THE ECLIPSE.

1870.

THE opening of the Eclipse Expedition was not propitious. Portsmouth, on Monday, December 5, 1870, was swathed by fog, which was intensified by smoke, and traversed by a drizzle of fine rain. At six P.M. I was on board the "Urgent." On Tuesday morning the weather was too thick to permit of the ship's being swung and her compasses calibrated. The Admiral of the port, a man of very noble presence, came on board. Under his stimulus the energy which the weather had damped appeared to become more active, and soon after his departure we steamed down to Spithead. Here the fog had so far lightened as to enable the officers to swing the ship.

At three P.M. on Tuesday, December 6, we got away, gliding successively past Whitecliff Bay, Bembridge, Sandown, Shanklin, Ventnor, and St. Catherine's Lighthouse. On Wednesday morning we sighted the Isle of Ushant, on the French side of the Channel. The northern end of the island has been fretted by the waves into detached tower-like masses of rock of very remarkable appearance. In the Channel the sea was green, and opposite Ushant it was a brighter green. On Wednesday evening we committed ourselves to the Bay of Biscay. The roll of the Atlantic was full, but not violent. There had been scarcely a gleam of sunshine throughout the day, but the cloud-forms were fine, and their apparent solidity impressive. On Thursday morning the green of the sea was displaced by a deep indigo blue. The whole of Thursday we steamed across the bay. We had little blue sky, but the clouds were again grand and varied--cirrus, stratus, cumulus, and nimbus, we had them all. Dusky hair-like trails were sometimes dropped from the distant clouds to the sea.

These were falling showers, and they sometimes occupied the whole horizon, while we steamed across the rainless circle which was thus surrounded. Sometimes we plunged into the rain, and once or twice, by slightly changing our course, avoided a heavy shower. From time to time perfect rainbows spanned the heavens from side to side. At times a bow would appear in fragments, showing the keystone of the arch midway in air, and its two buttresses on the horizon. In all cases the light of the bow could be quenched by a Nicol's prism, with its long diagonal tangent to the arc. Sometimes gleaming patches of the firmament were seen amid the clouds. When viewed in the proper direction, the gleam could be quenched by a Nicol's prism, a dark aperture being thus opened into stellar space.

At sunset on Thursday the denser clouds were fiercely fringed, while through the lighter ones seemed to issue the glow of a conflagration. On Friday morning we sighted Cape Finisterre--the extreme end of the arc which sweeps from Ushant round the Bay of Biscay. Calm spaces of blue, in which floated quietly scraps of cumuli, were behind us, but in front of us was a horizon of portentous darkness. It continued thus threatening throughout the day. Towards evening the wind strengthened to a gale, and at dinner it was difficult to preserve the plates and dishes from destruction. Our thinned company hinted that the rolling had other consequences. It was very wild when we went to bed. I slumbered and slept, but after some time was rendered anxiously conscious that my body had become a kind of projectile, with the ship's side for a target. I gripped the edge of my berth to save myself from being thrown out. Outside, I could hear somebody say that he had been thrown from his berth, and sent spinning to the other side of the saloon. The screw laboured violently amid the lurching; it incessantly quitted the water, and, twirling in the air, rattled against its bearings, causing the ship to shudder from stem to stern. At times the waves struck us, not with the soft impact which might be expected from a liquid, but with the sudden solid shock of battering-rams. 'No man knows the force of water,' said one of the officers,' until he has experienced a storm at sea.' These blows followed each other at quicker intervals, the screw rattling after each of them, until, finally, the delivery of a heavier stroke than ordinary seemed to reduce the saloon to chaos. Furniture crashed, glasses rang, and alarmed enquiries immediately followed. Amid the noises I heard one note of forced laughter; it sounded very ghastly. Men tramped through the saloon, and busy voices were heard aft, as if something there had gone wrong.

I rose, and not without difficulty got into my clothes. In the after-cabin, under the superintendence of the able and energetic navigating lieutenant, Mr. Brown, a group of blue-jackets were working at the tiller-ropes. These had become loose, and the helm refused to answer the wheel. High moral lessons might be gained on shipboard, by observing what steadfast adherence to an object can accomplish, and what large effects are heaped up by the addition of infinitesimals. The tiller-rope, as the blue-jackets strained in concert, seemed hardly to move; still it did move a little, until finally, by timing the pull to the lurching of the ship, the mastery of the rudder was obtained. I had previously gone on deck. Round the saloon-door were a few members of the eclipse party, who seemed in no mood for scientific observation. Nor did I; but I wished to see the storm. I climbed the steps to the poop, exchanged a word with Captain Toynbee, the only member of the party to be seen on the poop, and by his direction made towards a cleat not far from the wheel. [Footnote: The cleat is a T-shaped mass of metal employed for the fastening of ropes.] Round it I coiled my arms. With the exception of the men at the wheel, who stood as silent as corpses, I was alone.

I had seen grandeur elsewhere, but this was a new form of grandeur to me. The "Urgent" is long and narrow, and during our expedition she lacked the steadying influence of sufficient ballast. She was for a time practically rudderless, and lay in the trough of the sea. I could see the long ridges, with some hundreds of feet between their crests, rolling upon the ship perfectly parallel to her sides. As they approached, they so grew upon the eye as to render the expression 'mountains high' intelligible. At all events, there was no mistaking their mechanical might, as they took the ship upon their shoulders, and swung her like a pendulum. The deck sloped sometimes at an angle which I estimated at over forty-five degrees; wanting my previous Alpine practice, I should have felt less confidence in my grip of the cleat. Here and there the long rollers were tossed by interference into heaps of greater height. The wind caught their crests, and scattered them over the sea, the whole surface of which was seething white. The aspect of the clouds was a fit accompaniment to the fury of the ocean. The moon was almost full--at times concealed, at times revealed, as the scud flew wildly over it. These things appealed to the eye, while the ear was filled by the groaning of the screw and the whistle and boom of the storm.

Nor was the outward agitation the only object of interest to me. I was at once subject and object to myself, and watched with intense interest the workings of my own mind. The "Urgent" is an elderly ship. She had been built, I was told, by a contracting firm for some foreign Government, and had been diverted from her first purpose when converted into a troop-ship. She had been for some time out of work, and I had heard that one of her boilers, at least, needed repair. Our scanty but excellent crew, moreover, did not belong to the "Urgent," but had been gathered from other ships. Our three lieutenants were also volunteers. All this passed swiftly through my mind as the steamer shook under the blows of the waves, and I thought that probably no one on board could say how much of this thumping and straining the "Urgent" would be able to bear. This uncertainty caused me to look steadily at the worst, and I tried to strengthen myself in the face of it.

But at length the helm laid hold of the water, and the ship was got gradually round to face the waves. The rolling diminished, a certain amount of pitching taking its place. Our speed had fallen from eleven knots to two. I went again to bed. After a space of calm, when we seemed crossing the vortex of a storm, heavy tossing recommenced. I was afraid to allow myself to fall asleep, as my berth was high, and to be pitched out of it might be attended with bruises, if not with fractures. From Friday at noon to Saturday at noon we accomplished sixty-six miles, or an average of less than three miles an hour. I overheard the sailors talking about this storm. The "Urgent," according to those that knew her, had never previously experienced anything like it. [Footnote: 'There is, it will be seen, a fair agreement between these impressions and those so vigorously described by a scientific correspondent of the 'Times.']

All through Saturday the wind, though somewhat sobered, blew dead against us. The atmospheric effects were exceedingly fine. The cumuli resembled mountains in shape, and their peaked summits shone as white as Alpine snows. At one place this resemblance was greatly strengthened by a vast area of cloud, uniformly illuminated, and lying like a névé below the peaks. From it fell a kind of cloud-river strikingly like a glacier. The horizon at sunset was remarkable--spaces of brilliant green between clouds of fiery red. Rainbows had been frequent throughout the day, and at night a perfectly continuous lunar bow spanned the heavens from side to side. Its colours were feeble; but, contrasted with the black ground against which it rested, its luminousness was extraordinary.

Sunday morning found us opposite to Lisbon, and at midnight we rounded Cape St. Vincent, where the lurching seemed disposed to recommence. Through the kindness of Lieutenant Walton, a cot had been slung for me. It hung between a tiller-wheel and a flue, and at one A.M. I was roused by the banging of the cot against its boundaries. But the wind was now behind us, and we went along at a speed of eleven knots. We felt certain of reaching Cadiz by three. But a new lighthouse came in sight, which some affirmed to be Cadiz Lighthouse, while the surrounding houses were declared to be those of Cadiz itself. Out of deference to these statements, the navigating lieutenant changed his course, and steered for the place. A pilot came on board, and he informed us that we were before the mouth of the Guadalquivir, and that the lighthouse was that of Cipiòna. Cadiz was still some eighteen miles distant.

We steered towards the city, hoping to get into the harbour before dark. But the pilot who would have guided us had been snapped up by another vessel, and we did not get in. We beat about during the night, and in the morning found ourselves about fifteen miles from Cadiz. The sun rose behind the city, and we steered straight into the light. The three-towered cathedral stood in the midst, round which swarmed apparently a multitude of chimney-stacks. A nearer approach showed the chimneys to be small turrets. A pilot was taken on board; for there is a dangerous shoal in the harbour. The appearance of the town as the sun shone upon its white and lofty walls was singularly beautiful. We cast anchor; some officials arrived and demanded a clean bill of health. We had none. They would have nothing to do with us; so the yellow quarantine flag was hoisted, and we waited for permission to land the Cadiz party. After some hours' delay the English consul and vice-consul came on board, and with them a Spanish officer ablaze with gold lace and decorations. Under slight pressure the requisite permission had been granted. We landed our party, and in the afternoon weighed anchor. Thanks to the kindness of our excellent paymaster, I was here transferred to a more roomy berth.

Cadiz soon sank beneath the sea, and we sighted in succession Cape Trafalgar, Tarifa, and the revolving light of Ceuta. The water was very calm, and the moon rose in a quiet heaven. She swung with her convex surface downwards, the common boundary between light and shadow being almost horizontal. A pillar of reflected light shimmered up to us from the slightly rippled sea. I had previously noticed the phosphorescence of the water, but tonight it was stronger than usual, especially among the foam at the bows. A bucket let down into the sea brought up a number of the little sparkling organisms which caused the phosphorescence. I caught some of them in my hand. And here an appearance was observed which was new to most of us, and strikingly beautiful to all. Standing at the bow and looking forwards, at a distance of forty or fifty yards from the ship, a number of luminous streamers were seen rushing towards us. On nearing the vessel they rapidly turned, like a comet round its perihelion, placed themselves side by side, and, in parallel trails of light, kept up with the ship. One of them placed itself right in front of the bow as a pioneer. These comets of the sea were joined at intervals by others. Sometimes as many as six at a time would rush at us, bend with extraordinary rapidity round a sharp curve, and afterwards keep us company. I leaned over the bow, and scanned the streamers closely. The frontal portion of each of them revealed the outline of a porpoise. The rush of the creatures through the water had started the phosphorescence, every spark of which was converted by the motion of the retina into a line of light. Each porpoise was thus wrapped in a luminous sheath. The phosphorescence did not cease at the creature's tail, but was carried many porpoise-lengths behind it.

To our right we had the African hills, illuminated by the moon. Gibraltar Rock at length became visible, but the town remained long hidden by a belt of haze, through which at length the brighter lamps struggled. It was like the gradual resolution of a nebula into stars. As the intervening depth became gradually less, the mist vanished more and more, and finally all the lamps shone through it They formed a bright foil to the sombre mass of rock above them. The sea was so calm and the scene so lovely that Mr. Huggins and myself stayed on deck till near midnight, when the ship was moored. During our walking to and fro a striking enlargement of the disk of Jupiter was observed, whenever the heated air of the funnel came between us and the planet. On passing away from the heated air, the flat dim disk would immediately shrink to a luminous point. The effect was one of visual persistence. The retinal image of the planet was set quivering in all azimuths by the streams of heated air, describing in quick succession minute lines of light, which summed themselves to a disk of sensible area.

At six o'clock next morning, the gun at the Signal Station on the summit of the rock, boomed. At eight the band on board the 'Trafalgar' training-ship, which was in the harbour, struck up the national anthem; and immediately afterwards a crowd of mite-like cadets swarmed up the rigging. After the removal of the apparatus belonging to the Gibraltar party we went on shore. Winter was in England when we left, but here we had the warmth of summer. The vegetation was luxuriant--palm-trees, cactuses, and aloes, all ablaze with scarlet flowers. A visit to the Governor was proposed, as an act of necessary courtesy, and I accompanied Admiral Ommaney and Mr. Huggins to 'the Convent,' or Government House. We sent in our cards, waited for a time, and were then conducted by an orderly to his Excellency. He is a fine old man, over six feet high, and of frank military bearing. He received us and conversed with us in a very genial manner. He took us to see his garden, his palms, his shaded promenades, and his orange-trees loaded with fruit, in all of which he took manifest delight. Evidently 'the hero of Kars' had fallen upon quarters after his own heart. He appeared full of good nature, and engaged us on the spot to dine with him that day.

We sought the town-major for a pass to visit the lines. While awaiting his arrival I purchased a stock of white glass bottles, with a view to experiments on the colour of the sea. Mr. Huggins and myself, who wished to see the rock, were taken by Captain Salmond to the library, where a model of Gibraltar is kept, and where we had a useful preliminary lesson. At the library we met Colonel Maberly, a courteous and kindly man, who gave us good advice regarding our excursion. He sent an orderly with us to the entrance of the lines. The orderly handed us over to an intelligent Irishman, who was directed to show us everything that we desired to see, and to hide nothing from us. We took the 'upper line,' traversed the galleries hewn through the limestone; looked through the embrasures, which opened like doors in the precipice, towards the hills of Spain; reached St. George's hall, and went still higher, emerging on the summit of one of the noblest cliffs I have ever seen.

Beyond were the Spanish lines, marked by a line of white sentry-boxes; nearer were the English lines, less conspicuously indicated; and between both was the neutral ground. Behind the Spanish lines rose the conical hill called the Queen of Spain's Chair. The general aspect of the mainland from the rock is bold and rugged. Doubling back from the galleries, we struck upwards towards the crest, reached the Signal Station, where we indulged in 'shandy-gaff' and bread and cheese. Thence to O'Hara's Tower, the highest point of the rock. It was built by a former Governor, who, forgetful of the laws of terrestrial curvature, thought he might look from the tower into-the port of Cadiz. The tower is riven, and it may be climbed along the edges of the crack. We got to the top of it; thence descended the curious Mediterranean Stair--a zigzag, mostly of steps down a steeply falling slope, amid palmetto brush, aloes, and prickly pear.