Part 50

The multitude of experiments with mercury yielded many products, and often the same product by a different process which acquired a distinct name.

Turbith mineral was a secret preparation with Oswald Crollius who gave it this name, probably, it is supposed, on account of its resemblance in colour to the Turbethum (Convolvulus) roots which were in his time much used in medicine. It is a subsulphate, made by treating mercury with oil of vitriol and precipitating with water.

The precipitation of mercury by sal ammoniac was first described by Beguin in 1632. For a time it was given as a purgative and in venereal diseases. A double chloride of mercury and ammonium was also made by the alchemists and was highly esteemed by them, especially as it was soluble. It was called Sal Alembroth and also Sal Sapientiæ. The origin of the first name is unknown, but it has been alleged to be of Chaldean birth and to signify the key of knowledge.

A green precipitate was obtained by dissolving mercury and copper in nitric acid, and precipitating by vinegar. This was also used in syphilis.

Homberg put a little mercury into a bottle and attached it to the wheel of a mill. The metal was thereby transformed into a black powder (the protoxide.)

By a careful and very gradual precipitation of a solution of nitrate of mercury by ammonia Hahnemann obtained what he called soluble mercury. Soubeiran proved that this precipitate was a mixture in variable proportions of sub-nitrate and ammonio-proto-nitrate of mercury.

CALOMEL.

Calomel was introduced into practice by Sir Theodore Turquet de Mayerne about the year 1608. It has been said that he was the inventor of the product, but as it was described and, perhaps, to some extent used by other medical authorities, Crollius among these, who lived and died before Turquet was born, this was evidently impossible. Theodore Turquet de Mayerne had been a favourite physician to Henri IV, but he had been compelled to leave Paris on account of the jealousies of his medical contemporaries. His employment of mineral medicines, antimony and mercury especially, was the occasion of bitter attacks, but his professional heresy was perhaps actually less heinous than his firm Protestantism. Both James I and Charles I accepted his services and placed great confidence in his skill. He was instrumental, as explained in another section, in the independent incorporation of the apothecaries, and was also one of the most active promoters of the publication of the “London Pharmacopœia.”

It appears likely that Turquet invented the name by which this milder form of mercurial has come to be most usually known. The alchemical writers of the time called it Aquila Alba or Draco Mitigatus. A notorious Paracelsian of Paris, Joseph Duchesne, but better known by his Latinised surname of Quercetanus, who shared with Turquet the animosity of Gui Patin and his medical confederates, and for similar reasons, also made calomel and administered it, probably sold it, under the designation of the mineral Panchymagogon, purger of all humours. Panacea mercurialis, manna metallorum, and sublimatum dulce, were among the other fanciful names given. It was believed by the old medical chemists that the more frequently it was resublimed the more dulcified it became. In fact, resublimation was likely to decompose it, and thus to produce corrosive sublimate.

What the name “calomel” was derived from has been the subject of much conjecture. “Kalos melas,” beautiful black, is the obvious-looking source, but it does not seem possible to fit any sense to this suggested origin. A fanciful story of a black servant in the employ of de Mayerne manufacturing a beautiful white medicine is told by Pereira with the introduction of “as some say.” A good remedy for black bile is another far-fetched etymology, and another conceives the metal and the sublimate in the crucible as blackish becoming a fair white. Some thirty years ago, in a correspondence published in the “Chemist and Druggist,” Mr. T. B. Groves, of Weymouth, and “W. R.” of Maidstone, both independently broached the idea that “kalos” and “meli” (honey) were the constituents of the word, forming a sort of rough translation of the recognised term, dulcified mercury; a not unreasonable supposition, though this leaves the “kalos” not very well accounted for. In Hooper’s “Medical Dictionary” it is plausibly guessed that the name may have been originally applied to Ethiops Mineral, and got transferred to the white product; and Paris quotes from Mr. Gray the opinion that a mixture of calomel and scammony which was called the calomel of Rivierus may have been the first application of the term, meaning a mixture of a white and dark substance.

Beguin (1608) is generally credited with having been the first European writer to describe calomel. He gave it the name of “Draco mitigatus” (corrosive sublimate being the dragon). But Berthelot, in his “Chemistry of the Middle Ages,” has shown that the protochloride of mercury was prepared as far back as Democritus, and that it is described in certain Arab chemical writings. It is also alleged to have been prepared in China, Thibet, and India many centuries before it became known in Europe.

QUICKSILVER GIRDLES,

made by applying to a cotton girdle mercury which had been beaten up with the white of egg, were used in the treatment of itch before the true character of that complaint was understood.

BASILIC POWDER

was the old Earl of Warwick’s powder or Cornachino’s powder (equal parts of scammony, diaphoretic antimony, and cream of tartar), to which calomel, equal in weight to each of the other ingredients, was added. But I have not succeeded in tracing why or when the name of basilic (royal) was given to the compound.

CORROSIVE SUBLIMATE.

Van Swieten’s solution of corrosive sublimate was introduced in the middle of the eighteenth century as a remedy for syphilis, and for a long time was highly esteemed. Its author, Baron von Swieten, was of Dutch birth, and was a pupil of Boerhaave. He was invited to Vienna by the Empress Maria Theresa, and exercised an almost despotic authority in medical treatment. His original formula was 24 grains of corrosive sublimate dissolved in two quarts of whisky, a tablespoonful to be taken night and morning, followed by a long draught of barley-water.

Corrosive sublimate was the recognised cure for syphilis, at least in Vienna, at that time. Maximilian Locher, another noted physician of the same school, claimed to have cured 4,880 cases in eight years with the drug. This was in 1762.

CINNABAR.

The bisulphide of mercury (cinnabar) was also used in many nostrums. Paris says it was the active ingredient in Chamberlain’s restorative pills, “the most certain cure for the scrophula, king’s evil, fistula, scurvy, and all impurities of the blood.”

“KILLING” MERCURY.

The art of extinguishing or “killing” mercury has been discussed and experimented on from the fifteenth century until the present day. The modern use of steam machinery in the manufacture of mercurial ointment, mercurial pills, and mercury with chalk has put a check on the ingenuity of patient pharmacists, who were constantly discovering some new method for accelerating the long labour of triturating, which many operators still living can remember. Venice turpentine, or oil of turpentine, various essential oils, sulphur, the saliva of a person fasting, and rancid fat were among the earlier expedients adopted and subsequently discarded. The turpentines made the ointment irritating, the sulphur formed a compound, and the rancid fat was found to be worse than the turpentines. Nitrate of potash, sulphate of potash, stearic acid, oil of almonds and balsam of Peru, the precipitation of the mercury from its solution in nitric acid, spermaceti, glycerin, and oleate of mercury have been more modern aids.

It would be outside the purpose of this sketch to deal with the questions which the numerous processes suggested have raised. Apparently it is not completely settled now whether the pill, the powder, and the ointment depend for their efficiency on any chemical action such as the oxidation of the metal in the cases of the two former, or on a solution in the fat in the case of the ointment. These theories have been held, and do not seem unlikely; but there also seems good reason to believe that mercury in a state of minute division has definite physiological effects by itself. At any rate, it is well established that the more perfectly the quicksilver is “killed” the more efficient is the resulting compound.

SILVER.

The moon was universally admitted under the theory of the macrocosm and the microcosm to rule the head, and as silver was the recognised representative of Luna among the metals the deduction was obvious that silver was the suitable remedy for all diseases affecting the brain, as apoplexy, epilepsy, melancholia, vertigo, and failure of memory. Tachenius relates that a certain silversmith had the gift of being able to repeat word for word anything that he heard, and this power he attributed to his absorption of particles of silver in the course of his work. It does not appear, however, that all silversmiths were similarly endowed.

The Greek and Latin doctors make no allusion to silver as a medicine, and the earliest evidence of its actual employment as a remedy is found in the writings of Avicenna, who gave it in the metallic state “in tremore cordis, in fœtore oris.” He is also believed to have introduced the practice of silvering pills with the intention of thereby adding to their efficacy. To John Damascenus, a Christian saint who lived among the Arabs before Avicenna, is attributed the remark concerning silver, “Remedium adhibitum est, et in omnibus itaque capitis morbis, ob Lunæ, Argenti, et Cerebri sympathicam trinitatem.” This association of the moon, silver, and the brain was believed in firmly by the chemical doctors of the sixteenth century, and for a long time a tincture of the moon, tinctura Lunæ, was the most famous remedy in epilepsy and melancholia. A great many high authorities, among them Boyle, Boerhaave, and Hoffmann in the eighteenth century, continued to prescribe this tincture or the lunar pills, but silver gradually dropped out of fashion. A great number of medical investigators since have from time to time recommended the nitrate or the chloride of silver in various diseases, but without succeeding in securing for silver a permanent reputation as an internal medicine.

The Pilulæ Lunares were generally composed of nitrate of silver combined with opium, musk, and camphor. Nitrate of silver was given in doses varying from a twentieth to a tenth of a grain. The tincture of the moon was a solution of nitrate of silver with some copper, which gave it a blue tint and probably was the active medicinal ingredient. Fused nitrate of silver or lunar caustic seems to have succeeded to the reputation of fused caustic potash as a cautery, and also to have acquired the name of lapis infernalis (sometimes translated “hell-stone” in old books) originally applied to the fused potash.

The only reason assigned for this title is the keen pain caused by the application of the caustic, though probably it was first adopted to contrast it with the lapis divinus, which was a combination of sulphate of copper and alum used as an application to the eyes.