Part 2

To the organs of smell and taste in their natural condition, it is one of the most disgusting and loathsome of all the products of the vegetable kingdom.

Dr. Franklin ascertained, that the oily material, which floats upon the surface of water, upon a stream of tobacco smoke being passed into it, is capable, when applied to the tongue of a cat, of destroying life in a few minutes.

Mr. Brodie applied one drop of the empyreumatic oil of tobacco to the tongue of a cat; it occasioned immediate convulsions and an accelerated breathing. Five minutes after, the animal lay down on the side, and presented, from time to time, slight convulsive movements. A quarter of an hour after, it appeared recovered. The same quantity of the oil was applied again, and the animal died in two minutes.

In December, 1833, aided by several gentlemen of the medical class, and occasionally in the presence of other individuals, I made a number of experiments upon cats and other animals, with the distilled oil of tobacco.

EXPERIMENT 1.

A small drop of the oil was rubbed upon the tongue of a large cat. Immediately the animal uttered piteous cries and began to froth at the mouth.

In 1 minute the pupils of the eyes were dilated and the respiration was laborious. " 2-1/2 do. vomiting and staggering. " 4 do. evacuations; the cries continued, the voice hoarse and unnatural. " 5 do. repeated attempts at vomiting. " 7 do. respiration somewhat improved.

At this time a large drop was rubbed upon the tongue. In an instant the eyes were closed, the cries were stopped, and the breathing was suffocative and convulsed. In one minute the ears were in rapid convulsive motion, and, presently after, tremors and violent convulsions extended over the body and limbs. In three and an half minutes the animal fell upon the side senseless and breathless, and the heart had ceased to beat.

Slight tremors of the voluntary muscles, particularly of the limbs, continued, more or less, for nineteen minutes after the animal was dead. Those of the right side were observed to be more and longer affected than those of the left.

Half an hour after death the body was opened, and the stomach and intestines were found to be contracted and firm, as from a violent and permanent spasm of the muscular coat. The lungs were empty and collapsed. The left side of the heart, the aorta and its great branches were loaded with black blood. The right side of the heart and the two cavae contained some blood, but were not distended. The pulmonary artery contained only a small quantity of blood. The blood was every where fluid.

EXPERIMENT 2.

A cat was the subject of this experiment. The general effects were very much like those in the last, excepting, perhaps, that the oil operated with a little less energy. This cat was said to have lived for several years, in a room almost perpetually fumigated with tobacco smoke. The history of the animal employed in Experiment 1, was unknown.

EXPERIMENT 3.

Three drops of the oil of tobacco were rubbed upon the tongue of a full-sized, but young, cat. In an instant the pupils were dilated and the breathing convulsed; the animal leaped about as if distracted, and presently took two or three rapid turns in a small circle, then dropped upon the floor in frightful convulsions, and was dead in two minutes and forty-five seconds from the moment that the oil was put upon the tongue.

EXPERIMENT 4.

To the tongue of a young and rather less than half-grown cat, a drop of the oil of tobacco was applied. In fifteen seconds the ears were thrown into rapid and convulsive motions,--thirty seconds fruitless attempts to vomit. In one minute convulsive respiration; the animal fell upon the side. In four minutes and twenty seconds violent convulsions. In five minutes the breathing and the heart's motion had ceased. There was no evacuation by the mouth or otherwise. The vital powers had been too suddenly and too far reduced to admit of a reaction. The tremors, which followed death, subsided first in the superior extremities, and in five minutes ceased altogether. The muscles were perfectly flaccid.

EXPERIMENT 5.

In the tip of the nose of a mouse, a small puncture was made with a surgeon's needle, bedewed with the oil of tobacco. The little animal, from the insertion of this small quantity of the poison, fell into a violent agitation, and was dead in six minutes.

EXPERIMENT 6.

Two drops of the oil were rubbed upon the tongue of a red squirrel. This animal, so athletic as to render it difficult to secure him sufficiently long for the application, was in a moment seized with a violent agitation of the whole body and limbs, and was perfectly dead and motionless in one minute.

EXPERIMENT 7.

To the tongue of a dog rather under the middle size, five drops of the oil of tobacco were applied. In forty-five seconds he fell upon the side, got up, retched, and fell again. In one minute the respiration was laborious, and the pupils were dilated. In two minutes the breathing was slow and feeble, with puffing of the cheeks. In three minutes the pupils were smaller but continually varying. The left fore leg and the right hind leg were affected with a simultaneous convulsion or jerk, corresponding with the inspiratory motions of the chest. This continued for five minutes.

In nine minutes alimentary evacuations; symptoms abated; and the animal attempted to walk. At ten minutes two drops of the oil were applied to the tongue. Instantly the breathing became laborious, with puffing of the cheeks; pupils much dilated. The convulsive or jerking motions of the two limbs appeared as before, recurring regularly at the interval of about two seconds, and exactly corresponding with the inspirations. In twelve minutes the pupils were more natural; slight frothing at the mouth, the animal still lying upon the side. At this time a drop of the oil was passed into each nostril. The labor of the respiration was suddenly increased, the jaws locked.

In twenty-two minutes no material change; the jaws were separated and five drops of the oil were rubbed on the tongue. In one minute the pupils were entirely dilated, with strong convulsions. In one and an half minutes, in trying to walk, the animal fell. In three minutes the eyes rolled up, and convulsions continued. In six minutes, the plica semilunaris so drawn as to cover half the cornea. In seven minutes, slight frothing at the mouth. In forty minutes the inspirations were less deep, the convulsions had been unremitted, the strength failing. From this time he lay for more than half an hour nearly in the same state; the strength was gradually sinking, and as there was no prospect of recovery, he was killed. In this case, the true apoplectic puffing of the cheeks was present the greater part of the time.

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From the foregoing, and from additional experiments, which it is not necessary to give in detail, it appeared, that when applied to a wound made in the most sensitive parts of the integuments, the oil of tobacco, though it caused a good deal of pain, had a far less general effect than when applied to the tongue. Rats were less affected than cats. Two and sometimes three drops rubbed upon the tongue of a rat, did not kill in half an hour.

Three large drops rubbed upon the tongue of a full-sized cat, usually caused death in from three to ten minutes, and in one instance, already stated, in two minutes and forty-five seconds. One drop passed into the jugular vein of a large dog, occasioned an immediate cry, followed in a few moments by staggering, convulsive twitchings of the voluntary muscles, and vomiting.

In those cases in which full vomiting occurred, evident relief followed. Young animals suffered much more than those, which had come to their full growth and vigor. In those animals, whose lives were suddenly destroyed by the tobacco, no coagulation of the blood took place. The bodies of several cats were examined the next day after death, and only in a single instance was a slight coagulum observed; and this was in a cat, whose constitution possessed strong powers of resistance, and whose death was comparatively lingering.